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COMPARISON OF EMOTIONAL RESPONSES IN MONKEYS WITH RHINAL CORTEX OR AMYGDALA LESIONS

Meunier, PhD Martine and Bachevalier, PhD Jocelyne (2002) COMPARISON OF EMOTIONAL RESPONSES IN MONKEYS WITH RHINAL CORTEX OR AMYGDALA LESIONS. [Journal (Paginated)]

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Abstract

Four emotionally arousing stimuli were used to probe the behavior of monkeys with bilateral ablations of the entorhinal and perirhinal cortex. The animals’ behavioral changes were then contrasted with those observed earlier (Meunier et al., 1999) in monkeys with either neurotoxic or aspiration lesions of the neighboring amygdala. Rhinal cortex ablations yielded several subtle behavioral changes, but none of them resembled any of the disorders typically seen after amygdalectomies. The changes produced by rhinal damage took mainly the form of heightened defensiveness, and attenuated submission and approach responses, that is, just the opposite of some of the most distinctive symptoms following amygdala damage. These findings raise the possibility that the rhinal cortex and amygdala have distinct, interactive, functions in normal behavioral adaptation to affective stimuli.

Item Type:Journal (Paginated)
Keywords:monkey, amygdala, emotion, fear
Subjects:Neuroscience > Neuropsychology
Biology > Animal Cognition
Biology > Primatology
Biology > Behavioral Biology
Neuroscience > Behavioral Neuroscience
Biology > Animal Behavior
ID Code:2872
Deposited By: Meunier, Martine
Deposited On:15 Apr 2003
Last Modified:11 Mar 2011 08:55

References in Article

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Akert K, Gruesen R.A., Woolsey CN, Meyer DR (1961) Klüver-Bucy syndrome in monkeys with neocortical ablations of temporal lobe. Brain 84:480-498.

Aggleton JP and Passingham RE (1981) Syndrome produced by lesions of the amygdala in monkeys (Macaca mulatta). J Comp Physiol Psychol 95:961-977.

Baxter MG, Saunders RC, Murray EA. (1998) Aspiration lesions of the amygdala interrupt connections between prefrontal cortex and temporal cortex in rhesus monkeys. Soc Neurosci Abstr 24:1905.

Blood AJ, Zatorre RJ, Bermudez P, Evan AC (1999) Emotional responses to pleasant and unpleasant music correlate with activity in paralimbic brain regions. Nature Neurosci. 2:382-387.

Brothers L, Ring B (1993) Mesial temporal neurons in the macaque monkey with responses selective for aspects of social stimuli. Behav. Brain Res. 57:53-61.

Emery NJ and Amaral DG (1999) The role of the amygdala in primate social cognition. In: Cognitive Neuroscience of Emotion (Lane RD, Nadel L, eds), pp156-191. Oxford: Oxford UP.

Emery NJ, Capitanio JP, Mason WA, Machado CJ, Mendoza SP, Amaral DG (2001) The effects of bilateral lesions of the amygdala on dyadic social interactions in rhesus monkeys (Macaca mulatta). Behav Neurosci, in press.

Erickson CA, Desimone R (1999) Responses of macaque perirhinal neurons during and after visual stimulus association learning. J Neurosci 19:10404-16.

Erickson CA, Jagadeesh B, Desimone R (2000) Clustering of perirhinal neurons with similar properties following visual experience in adult monkeys. Nat Neurosci 3:1143-48.

Franzen, E.A. & Myers, R.E. (1973) Neural control of social behavior: prefrontal and anterior temporal cortex. Neuropsychologia, 11, 141-157.

Goosen C (1981) Abnormal behavior patterns in rhesus monkeys: symptoms of mental disease? Biol Psychiatry 16:697-716.

Goulet S, Doré FY, Murray EA (1998) Aspiration lesions of the amygdala disrupt the rhinal corticothalamic projection system in rhesus monkeys. Exp Brain Res 199:131-140.

Higuchi SI, Miyashita Y (1996) Formation of mnemonic neuronal responses to visual paired associates in inferotemporal cortex is impaired by perirhinal and entorhinal lesions. Proc Natl Acad Sci USA 93: 739-743.

Horel JA, Misantone LJ (1974) The Klüver-Bucy syndrome produced by partial isolation of the temporal lobe. Exp Neurol 42:585-594.

Horel JA, Keating EG, Misantone LJ (1975) Partial Klüver-Bucy syndrome produced by destroying temporal neocortex or amygdala. Brain Res. 94:347-359.

Isenberg N, Silbersweig D, Engelien A, Emmerich S, Malavade K, Beattie B, Leon AC, Stern E (1999) Linguistic threat activates the human amygdala. Proc Natl Acad Sci USA 96:10456-59.

Iwai E, Nishio T, Yamagucchi K (1986) Neuropsychological basis of a K-B sign in Klüver-Bucy syndrome produced following total removal of inferotemporal cortex of macaque monkeys. In: Emotion: Neural and Chemical Control (Oomura Y, ed), pp299-311. Tokyo:Japan Scientific Society Press.

Kalin NH, Shelton SE, Davidson RJ, Kelley AE (2001) The primate amygdala mediates acute fear but not the behavioral and physiological components of anxious temperament. J Neurosci 21:2067-74.

Kling AS (1974). Differential effects of amygdalectomy in male and female nonhuman primates. Arch Sexual Behav 3:129-134.

Kling AS, Brothers L (1992) The amygdala and social behavior. In: The Amygdala: Neurobiological aspects of emotion, memory, and mental dysfunction (Aggleton JP, ed), pp.353-377. New York: Wiley-Liss.

Kling AS, Steklis HD (1976) A neural substrate for affiliative behavior in non-human primates. Brain Behav Evol, 13:216-238.

Kling AS, Lloyd RL, Perryman KM (1987) Slow wave changes in amygdala to visual, auditory, and social stimuli following lesions of the inferior temporal cortex in squirrel monkey (Saimiri sciureus). Behav Neural Biol 47: 54-72.

KlingAS, Tachiki K, Lloyd R (1993) Neurochemical correlates of the Klüver-Bucy syndrome by in vivo microdyalisis in monkey. Behav Brain Res 56:161-170.

Klüver H and Bucy P (1939) Preliminary analysis of functioning of the temporal lobes in monkeys. Arch. Neurol. Psychiat. 42:979-1000.

Liu Z, Richmond BJ (2000) Response differences in monkey TE and perirhinal cortex: stimulus association related to reward schedules. J Neurophysiol 83:1677-92.

Liu Z, Murray EA, Richmond BJ (2000) Learning motivational significance of visual cues for reward schedules requires rhinal cortex. Nat Neurosci 3:1307-15.

Lloyd RL, Kling AS (1991) Delta activity from amygdala in squirrel monkeys (Saimiri sciureus): Influence of social and environmental context. Behav Neurosci 105: 223-229.

Machado CJ, Bachevalier J (2000) Selective lesions to the amygdala, hippocampus or orbital frontal cortex alter reactivity to a human intruder in monkeys. Soc Neurosci Abstr 26:

Málková L, Mishkin M, Suomi SJ, Bachevalier J (1997) Socioemotional behavior in adult rhesus monkeys after early versus late lesions of the medial temporal lobe. Ann NY Acad Sci 807:538-540.

Meunier M, Bachevalier J, Murray EA, Merjanian PM, Richardson R (1991) Effects of rhinal cortical or limbic lesions on fear reactions in rhesus monkeys. Soc Neurosci Abstr 17:337.

Meunier M, Murray EA, Bachevalier J, Mishkin M (1993) Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys. J Neurosci 13: 5418-5432.

Meunier M, Hadfield W, Bachevalier J, Murray EA (1996) Effects of rhinal cortex lesions combined with hippocampectomy on visual recognition memory in rhesus monkey. J Neurophysiol 75: 1190-1205.

Meunier M, Bachevalier J, Murray EA, Málková L, Mishkin M (1999) Effects of aspiration vs neurotoxic lesions of the amygdala on emotional responses in monkeys. Eur J Neurosci 11:4403-4418.

Meyer DR (1972) Some features of the dorsolateral frontal and inferotemporal syndromes in monkeys. Acta Neurobiol Exp (Warszawa) 32:235-260.

Mineka S, Cook M (1988) Social learning and the acquisition of snake fear in monkeys. In: Social Learning: Psychosocial and Biological Perspectives (Zentall T, Galef B, eds), pp. 51-73. Hillsdale, NJ: Erlbaum.

Mirsky, A. F. (1960). Studies of the effects of brain lesions on social behaviors in Macaca mulatta: Methodological and theoretical considerations. Annals of the New York Academy of Science, 85, 785-94.

Murray EA (1996) What have ablation studies told us about the neural substrates of stimulus memory? Semin Neurosci 5:10-20.

Murray EA, Bussey TJ (1999) Perceptual-mnemonic functions of the perirhinal cortex. Trends Cogn Sci 3:142-151.

Murray EA, Gaffan EA, Flint RW Jr (1996) Anterior rhinal cortex and amygdala: dissociation of their contributions to memory and food preference in rhesus monkeys. Behav Neurosci 110:30-42.

Myers RE, Swett C (1970) Social behavior deficits of free-ranging monkeys after anterior temporal cortex removal: a preliminary report. Brain Res 18:551-556.

Otto T, Cousens G, Herzog C (2000) Behavioral and neuropsychological foundations of olfactory fear conditioning. Behav Brain Res 110:119-28.

Raleigh MJ, Steklis HD (1981) Effects of orbitofrontal and temporal neocortical lesions on the affiliative behavior of Vervet monkeys (Cercopithecus aethiops sabaeus). Exp Neurol 73:378-389.

Rosvold HE, Mirsky AF, Pribram KH (1954) Influence of amygdalectomy on social behavior in monkeys. J Comp Physiol Psychol 47:173-178.

Suomi SJ (1982) Abnormal behavior and primate models of psychopathology. In: Primate Behavior (XXX ed), pp 171-215. New York: Academic Press.

Suzuki WA (1996). The anatomy, physiology and functions of the perirhinal cortex. Curr Op Neurobiol 6:179-186.

Weiskrantz L (1956) Behavioral changes associated with ablation of the amygdaloid complex in monkeys. J Comp Physiol Psychol 49:381-391.

Whalen, P.J. (1998) Fear, vigilance, and ambiguity: Initial neuroimaging studies of the human amygdala. Curr Dir Psychol Sci 7:177-188.

Zola-Morgan S, Squire LR, Alvarez-Royo P, Clower RP (1991) Independence of memory functions and emotional behavior: separate contributions of the hippocampal formation and the amygdala. Hippocampus 1:207-220.

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