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Glutathione S-Transferase activity and total thiol status in chronic alcohol abusers before and 30 days after alcohol abstinence

Muttigi, MS and Prabhu, LS and Kedage, V and Prakash, M and Shetty, JK and Virupaksha, D and Bhandary, PV (2009) Glutathione S-Transferase activity and total thiol status in chronic alcohol abusers before and 30 days after alcohol abstinence. [Journal (On-line/Unpaginated)]

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Abstract

Background: Glutathione S Transferase (GST) has been involved in detoxification process in the liver and its activity has been shown to be increased in alcohol abusers. In the current work we measured the GST activity, total thiol status, AST, ALT, and direct bilirubin in chronic alcohol abusers before and 30 days after alcohol abstinence and lifestyle modification. Methods: Serum and urine GST activity and total thiol status were determined using spectrophotometric methods and serum transaminases were determined using clinical chemistry analyzer. Results: We found,significant increase in serum and urine GST (p<0.001), AST (p<0.001), ALT (p<0.001), and decrease in total thiol status (p<0.001) in chronic alcohol abusers. GST activity significantly decreased (p<0.001) and total thiol status were improved significantly (p<0.001) 30 days after alcohol abstinence and lifestyle modification. Conclusion: This study provides preliminary data to suggest the role of GST as prognostic indicator of alcohol abstinence with possible trend towards an improvement in liver function.

Item Type:Journal (On-line/Unpaginated)
Keywords:Glutathione S Transferase; Total thiols; Alcoholic liver disease; Alcohol abstinence
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:6563
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:02 Jul 2009 01:45
Last Modified:11 Mar 2011 08:57

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