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Antipsychotics and Sexual Dysfunction :Sexual Dysfunction - Part III

Nagaraj, AKM and Pai, NB and Rao, S (2009) Antipsychotics and Sexual Dysfunction :Sexual Dysfunction - Part III. [Journal (On-line/Unpaginated)]

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Abstract

Satisfying sexual experience is an essential part of a healthy and enjoyable life for most people. Antipsychotic drugs are among the various factors that affect optimal sexual functioning. Both conventional and novel antipsychotics are associated with significant sexual side effects. This review has presented various studies comparing different antipsychotic drugs. Dopamine antagonism, increased serum prolactin, serotonergic, adrenergic and cholinergic mechanisms are all proposed to be the mechanisms for sexual dysfunction. Drug treatment for this has not given satisfactory long-term results. Knowledge of the receptor pharmacology of an individual antipsychotic will help to determine whether it is more or less likely to cause sexual side effects and its management.

Item Type:Journal (On-line/Unpaginated)
Keywords:Sexual dysfunction, Desire, Erection, Orgasm, Ejaculation, Antipsychotics
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
Neuroscience > Neuropsychiatry
ID Code:6949
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:13 Sep 2010 03:56
Last Modified:11 Mar 2011 08:57

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Schiavi RC, Segraves RT. The biology of sexual function. Psychiatr Clin North Am 1995;18(1):7-23.

2. Smith SM, O' Keane V, Murray R. Sexual dysfunction in patients taking conventional antipsychotic medication. Br J Psychiatry 2002;181:49-55.

3. Wirshing DA, Joseph MP, Marder SR, Saunders CS, Wirshing WC. Sexual side effects of novel antipsychotic medications. Schizophr Res 2002;56:25-30.

4. Compton MT, Miller AH. Sexual side effects associated with conventional and atypical antipsychotic. Psychopharmacol Bull 2001;54(3):89-108.

5. Compton MT, Miller AH. Antipsychotic induced hyperprolactinemia and sexual dysfunction. Psychopharmacol Bull 2002;36:143-164.

6. Culter AJ. Sexual dysfunction and antipsychotic treatment. Psychonendoendocrinology 2002;28 (suppl 1):69-82.

7. Segraves RT. Effects of psychotropic drugs on human erection and ejaculation. Arch Gen Psychiatry 1989;46:275-84.

8. Konarzewska B, Szulc A, Poptawska R, Galinska B, Juchnowicz D. Impact of neuroleptic-induced hyperprolactinemia on sexual dysfunction in male schizophrenic patients. Psychiatr Pol. 2008;42(1):87-95.

9. Costa AM, de Lima MS, Faria M, Filho SR, de Olivera JR et al. A naturalistic 9 month follow up comparing olanzapine and conventional antipsychotics on sexual dysfunction and hormonal profile for males with schizophrenia. J Psychopharmacol 2007 Mar;1(2):165-70.

10. Smith SM. The impact of hyperprolactinemia on sexual function in patients with psychosis. J Psychopharmacol. 2008 Mar;22(2 suppl):63-9.

11. Kotin J, Wilbert DE, Verburg D, Soldinger SM. Thioridazine and sexual dysfunction. Am J Psychiatry 1976;133:82-85.

12. Ghadirian AM, Chouinard G, Annable L . Sexual dysfunction and prolactin levels in neuroleptic treated Schizophrenic outpatients. J Nerv Ment Dis 1982;170:463-467.

13. Burke MA, McEvoy JP, Ritchie JC. A pilot study of a structured interview addressing sexual function in men with Schizophrenia. Biol Psychiatry 1994;35:32-35.

14. Aizenberg D, Zemishlany Z, Dolfman-Etrog P, Weizman A. Sexual dysfunction in male Schizophrenic patients. J Clin Psychiatry 1995;56:137-141.

15. Kockott G, Pfeiffer W. Sexual disorders in non acute psychiatric outpatients. Comprehensive psychiatry 1996;37(1):56-61.

16. Raja M, Azzoni A. Sexual behaviour and sexual problems among patients with severe chronic psychosis. Eur Psychiatry 2003;18:70-76.

17. Hummer M, Kemmler G, Kurz M, Kurzthaler I, Oberbaner H, Fleishhacker WW. Sexual disturbances during clozapine and haloperidol treatment for schizophrenia. Am J Psychiatry 1999;156:631-633.

18. Aizenberg D, Modai I, Landa A, Gil-Ad I, Weizman A. Comparison of sexual dysfunction in male Schizophrenic patients maintained on treatment with classical antipshchotics versus Clozapine. J Clin Psychiatry 2001; 62: 541-544.

19. MacDonald S, Halliday J, MacEwan T, Sharkey V, Farrignton S, Wall S, McCreadic RG. Nithsdale Schizophrenia surveys 24: sexual dysfunction. Br J Psychiatry 2003;182:50-56.

20. Bobes J, Gare A, Portilla MP, Rejas J et al. Frequency of sexual dysfunction and other reproductive side-effects in patients with Schizophrenia treated with risperidone, olanzepine, quetiapine, or haloperidol: the results of the EIRE study. J Sex Marital Ther 2003;29(2):125-47.

21. Kelly DL, Conley RR. A randomized double-blind 12 week study of quetiapine, risperidone or fluphenazine on sexual functioning in people with schizophrenia. Psychoneuroendocrinology 2006;31(3):340-6.

22. Knegtering R, Casrelein A, Bous H, Van Der Linsle I. A randomized open label study of impact of quetiapine versus risperidone on sexual functioning. J Clin Psychopharmacol 2004;24(1):56-61.

23. Byerly MJ, Lescouflair E, Weber MT, Bugno RM, Fisher R et al. An open label treatment of quetiapine for antipsychotic-induced sexual dysfunction. J Sex Marital Ther 2004;30(5):325-32.

24. Melkersson K. Differences in prolactin elevation and related symptoms of atypical antipsychotics in schizophrenic patients. J Clin Psychiatry 2005;66(6):761-7.

25. Montejo Gonzalez AL, Rico-Villademoros F, Tafalla M, Majadas S; Spanish Working Group for the Study of Psychotropic-Related Sexual Dysfunction. A 6-month prospective observational study on the effects of quetiapine on sexual functioning. J Clin Psychopharmacol. 2005 Dec;25(6):533-8.

26. Atmaca M, Kuloglu M, Tezcan E. A new atypical antipsychotic: quetiapine-induced sexual dysfunctions. Int J Impot Res 2005;17(2):201-3.

27. Byerly MJ, Nakonezny PA, Bettcher BM, Carmody T, Fisher R et al. Sexual dysfunction associated with second-generation antipsychotics in outpatients with schizophrenia or schizoaffective disorder: An empirical evaluation of olanzapine, risperidone, and quetiapine. Schizophrenia Research. 2006;81(2-3):311-16.

28. Knegtring H, Van den Bosch R, Castelein S, Bruggeman R, Sytema S et al. Are sexual side effects of prolactin-rising antipsychotics reducible to serum prolactin? Psychoneuroendocrinology. 2008 Jul;33(6):111-7.

29. Dickson RA, Glazer WM. Neuroleptic induced hyperprolactinemia. Schizophr Res. 1999;35:75-86.

30. Dickson RA, Seeman MV, Corenblum B. Hormonal side effects in women: typical versus atypical antipsychotic treatment. J Clin Psychiatry. 2000;61(suppl 3):10-15.

31. Rajiv Tandon. Safety and tolerability: how do newer generation ‘atypical’ antipsychotics compare? Psychiatric Quarterly. 2002;73(4);297-311.

32. Zajecka J, Fawcett J, Schaff M, Jeffriess H, Guy C. The role of serotonin in sexual dysfunction: fluoxetine associated orgasm dysfunction. J Clin Psychiatry 1991;52(2):66-8.

33. Thorner MO, Besser GM. Bromocriptine treatment of hyperprolactinemic hypogonadism. Acta Endocrinol (Copenh). 1978;88:131-146.

34. Matsuoka I, Nakai T, Miyake M, Hirai M, Ikawa G. Effects of bromocriptine on neuroleptic-induced amenorrhea, galactorrhea and impotence. Jpn J Psychiatry Neurol. 1986;40(4):639-46.

35. Valevski A, Modai I, Zbarski E, Zemishlany Z, Weizman A. Effect of amantadine on sexual dysfunction in neuroleptic-treated male schizophrenic patients. Clin Neuropharmacol. 1998;21(6):355-7.

36. Tollin SR. Use of the dopamine agonists bromocriptine and cabergoline in the management of risperidone-induced hyperprolactinemia in patients with psychotic disorders. J Endocrinol Invest. 2000;23(11):765-70.

37. Benatov R, Reznik I, Zemishlany Z. Sildenafil citrate (Viagra) treatment of sexual dysfunction in a schizophrenic patient. Eur Psychiatry. 1999;14(6):353-5.

38. Lare SB, Labbate LA. Sildenafil and erectile dysfunction. Am J Psychiatry. 2000;157(12):2055-6.

39. Atmaca M, Kuloglu M, Tezcan E. Sildenafil use in patients with olanzapine-induced erectile dysfunction. Int J Impot Res. 2002;14(6):547-9.

40. Aviv A, Shelef A, Weizman A. An open-label trial of sildenafil addition in risperidone-treated male schizophrenia patients with erectile dysfunction. J Clin Psychiatry. 2004;65(1):97-103.

41. Yamada K, Kanba S, Yagi G, Asai M. Effectiveness of herbal medicine (shakuyaku-kanzo-to) for neuroleptic-induced hyperprolactinemia. J Clin Psychopharmacol. 1997;17(3):234-5.

42. Yamada K, Kanba S, Yagi G, Asai M. Herbal medicine (Shakuyaku-kanzo-to) in the treatment of risperidone-induced amenorrhea. J Clin Psychopharmacol. 1999;19(4):380-1.

43. Nemeth A, Arato M, Trener T. Treatment of fluvoxamine induced anorgasmia with a partial drug holiday. American J Psychiatry. 1996;153(10):13-15.

44. Montejo AL, Llorca G, Izquierdo JA et al. Incidence of sexual dysfunction associated with antidepressant agents: A prospective multicentre study of 1022 patients. J Clinical Psychiatry. 2001;62(Suppl 3):10-20.

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