The Response of Serum Cortisol and Leptin Levels to Academic Stress

Elizabeth, J and Dayananda, G and Kusumadevi, MS and Sunil, KC and Sujayasri, S and Suhas , S (2009) The Response of Serum Cortisol and Leptin Levels to Academic Stress. [Journal (On-line/Unpaginated)]

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Background: Medical students are subjected to various types of stress during the academic course and they react differently. This study is an attempt to establish a relationship between the coping abilities, serum cortisol and leptin levels in response to academic examination stress in first year medical students. Methods: Thirty four 1st year medical students between 18 to 21 yrs of age were randomly selected and their coping abilities were assessed using the State Trait Anxiety Inventory. Two fasting blood samples were drawn, one on the day of examination (Situation I) and the second after the completion of the examination (Situation II). Serum cortisol and leptin levels were estimated using a standardized RIA Kit and the levels obtained were correlated with the psychometric data. Results: The results showed increased levels of cortisol prior to examination in the poor adjusters in comparison to the good adjusters. The levels of cortisol decreased after examination in both good and poor adjusters with the poor adjusters showing higher levels. On the other hand, leptin levels increased in good adjusters in comparison with poor adjusters in Situation I and in Situation II the good adjusters showed a marginal decrease and poor adjusters maintained the same levels of leptin. Conclusion: Cortisol and leptin respond inversely to academic stress. Cortisol levels sharply decline from stressful to post-stressful situation indicating the wane of stress.

Item Type:Journal (On-line/Unpaginated)
Keywords:Academic stress, Cortisol, Leptin, State Trait Anxiety Inventory
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:6954
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:13 Sep 2010 03:56
Last Modified:11 Mar 2011 08:57

References in Article

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1. Al-Ayadi.L. Neurohumoral changes in medical students during academic stress. Ann Saudi Med 2005;25(1):36-40

2. Lucie M, Karin OH, Stefan W et al. Anticipated academic examinations induse distinct cortisol response in adolescent pupils. Neuroendocrinol lett 2003;24(6):449-453

3. Armario A, Marti O, Molina T et al. Acute stress markers in humans: Response of plasma glucose, cortisol and prolactin to two examination differing in the anxiety they provoke. Psychoneuroendocrinol 1996;212:17-24

4. Lacey K, Zaharia MD, Griffiths J et al. Prospective study of neuroendocrine and immune alteration associated with the stress of an oral academic examination among graduate students. Psychoneuroendocrinol 2000;25:339-56

5. Lucini D, Norbiato G, Clerici M et al. Haemodynamic and autonomic adjustments to real life stress conditions in humans. Hypertension 2002;39:184-8

6. Madelon P, Guido RG, Rudy B et al. Immune responses to experimental stress: effects of mental effort and uncontrollability. Psychosom Med. 1999;61:513-524.

7. Olff M. Stress, depression and immunity the role of defence and coping styles. Psychiatry Res 1999;85(1):17-31

8. Bohnen N. Coping reactivity and coping performance in a continuous mental task paradigm. Biological Psychology. 1990;31:107-116

9. Shih CL, Ming BL, Yue JL et al. Hyperleptinemia in subjects with persistent partial post traumatic stress disorder after a major earthquake. Endocrinol Rev1986;7:284-301

10. Kain ZN, Zimolo Z and Heninger G. Leptin and perioperative neuroendocrinological stress response. J Clin Endocrinol Metab 1999;84:2438-2442

11. Bronstein SR, Licinio J, Tauchnitz R et al. Plasma leptin levels are increased in survivors of acute sepsis: associated loss of diurnal rhythm in cortisol and leptin secretion. J Clin Endocrinol Metab 1998;83:282-283

12. Sliwowski Z, Lorens K, Konturek SJ et al. Leptin, gastrointestinal and stress hormones in response to exercise in fasted or fed subjects and before or after blood donation. J Physiol Pharmacol 2001;52:53-70

13. Zhang Y, Proenca R, Maffei M et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432

14. Dallman MF, Stack AM, Akana SF et al. Feast and famine: a critical role of glucocorticoids with insulin in daily energy flow. Front Neuroendocrinol 1993;14:303-347

15. Askari H, Lie J, Dagogo JS. Hormonal regulation of human leptin in vivo: effects of hydrocortisone and insulin. Int J Obes 2000;24:1254-1259

16. Spielberger CD, Gorsuch RL and Lushene RE. In SAI Manual for the State- Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press; 1970.

17. Bernard Rosner. Fundamentals of Biostatistics. 5th ed. Duxbury; 2000.

18. Licinio J, Mantzoros C, Negaro AB et al. Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med 1997;3:575-579


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