Cogprints

Urinary Peptide Levels in Patients with Chronic Renal Failure

Mungli, Prakash and Phani, Nagaraj M and R, Kavya and M, Supriya (2010) Urinary Peptide Levels in Patients with Chronic Renal Failure. [Journal (On-line/Unpaginated)]

Full text available as:

[img]
Preview
 PDF - Published Version
Available under License Creative Commons Attribution No Derivatives.
171Kb

Abstract

Introduction: Peptide levels in urine are found to be decreased in renal failure. In the current study urinary peptide levels were determined in chronic renal failure (CRF) patients. Method: 86 CRF patients and 80 healthy controls were selected for the study. Urinary proteins and peptide levels were determined by spectrophotometer based Lowry and Bradford methods. Urinary creatinine levels were determined by clinical chemistry analyzer. Results: There was significant decrease in urinary peptide levels in CRF patients and Urinary % peptides were significantly decreased in CRF patients as compared to healthy controls. Urinary % peptides correlated negatively with proteinuria. Conclusion: we have found decrease in urinary peptides and % urinary peptides in CRF patients and possibly measurement of % urinary peptides may possibly serve as better indicator in early detection of impairment in renal function.

Item Type:Journal (On-line/Unpaginated)
Keywords:Peptiduria; Proteinuria; Chronic renal failure; Urinary peptides
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:6969
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:22 Nov 2010 14:20
Last Modified:11 Mar 2011 08:57

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Skorecki K, Green J, Brenner BM. Chronic renal failure. In: Harrisons principles of internal medicine, Kasper DL, Braunwald E, Fauci AS (Editors), 16th edition, McGraw-Hill, New York, page 1663-7.

2. Gerstein HC, Mann JF, Yi Q. Albuminuria and risk of cardiovascular events, death and heart failure in diabetic and nondiabetic individuals. JAMA 2001;286:421-6.

3. Mann JF, Gerstein HC, Pogue J, Bosch J, Yusuf S. Renal insufficiency as a predictor of cardiovascular outcomes and the impact of ramipril: the HOPE randomized trial. Ann Intern Med 2001;134:629-36.

4. Burton C, Harris KPG. The role of proteinuria in the progression of chronic renal failure. Am J Kidney Dis 1996;27:765-75.

5. Lemley K. Proteinuria or peptiduria: where’s the beef? J Lab Clin Med 2005;145:228-230.

6. Maack T, Park CH, Camargo MJ. Renal filtration and metabolism of proteins. In: The Kidney, physiology and pathophysiology. Seldin DW, Giebish G (editors), New York, 1985: page 1773-804.

7. Gudehithlu KP, Pegoraro AA, Dunea G, Arruda JAL, Singh A. Degradation of albumin by the renal proximal tubule cell and the subsequent fate of its fragments. Kidney Int 2004;65:2113-2122.

8. Osicka TM, Pratt LM, Comper WD. Glomerular capillary wall permeability to albumin and horseradish peroxidase. Nephrology 1996;2:199-212.

9. Osicka TM, Comper WD. Protein degradation during renal passage in normal kidneys is inhibited in experimental albuminuria. Clin Sci 1997;93:65-72.

10. Osicka TM, Panagiotopoulos S, Jerums G, Comper WD. Fractional clearance of albumin is influenced by albumin degradation. Clin Sci 1997;93:557-564.

11. Burne MJ, Panagiotopoulos S, Jerums G, Comper WD. Alterations in renal Degradation of albumin in early experimental diabetes: a new factor in the mechanism of albuminuria. Clin Sci 1998;95:67-72.

12. Prakash M, Shetty JK, Dash S, Barik BK, Sarkar A, Prabhu R. Determination of urinary peptides in patients with proteinuria. Indian J Nephrol 2008;18:150-54.

13. Lowry OH, Rosenbrough NJ, Farr AI, Randall RT. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.

14. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of proteins utilizing the principle of protein dye binding. Anal Biochem 1976;72:248-54.

15. Russo LM, Bakris G, Comper W. Renal handling of albumin: a critical review of basic concept and perspective. Am J Kidney Dis 2002;39:899-919.

16. Singh A, Gudehithlu KP, Le G, Litbarg NO, Khalili V, Vernik J, Hart P, Arruda JAL, Dunea G. Decreased urinary peptide excretion in patients with renal disease. Am J Kidney Dis. 2004;44:1031-1038.

Metadata

Repository Staff Only: item control page

Cogprints is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.