A Study on Ajuga bracteosa wall ex. Benth for analgesic activity

Akriti Pal , RS Pawar, Int J Cur Bio Med Sci. (2011) A Study on Ajuga bracteosa wall ex. Benth for analgesic activity. [Journal (Paginated)]

Full text available as:

PDF (A Study on Ajuga bracteosa wall ex. Benth for analgesic activity) - Published Version
Available under License Creative Commons Attribution No Derivatives.



Ethnopharmacological relevance: Ajuga bracteosa wall ex. Benth (Labiatae) is traditionally used medicine in the treatment of malaria and gout. The plant is substitute of cinchona. Its allied species Ajuga Parviflora is also found sporadically. In Ayurvedic prepration the aqueous extract of the leaves part showed diuretic activity. Aim of the study: The present study was carried out to investigate analgesic activity of Ajuga bracteosa wall ex. Benth aerial part extracts. Materials and methods: A. bracteosa, a widespread medicinal plant traditionally used in the disease, was collected from Hamirpur district of Himachal Pradesh. Aerial part was extracted with petroleum ether, chloroform, methanol, ethanol and water. Analgesic activity of these extracts was assessed in swiss albino mice with acetic acid-induced writhing test and tail immersion test. Results: At the doses used (200 and 400 mg/kg, i.p.) chloroform and water extracts showed significant and dose-dependent analgesic effects. Conclusion: Our results indicate that extracts Ajuga bracteosa wall ex. Benth obtained from demonstrate an analgesic effect probably mediated by opioid receptors.

Item Type:Journal (Paginated)
Keywords:Ajuga bracteosa, Analgesics, Tail immersion test, acetic acid-induce writhing test.
ID Code:7313
Deposited By: CurrentSciDirect Publications, International Journal of Current Biological and Medical Science (IJCBMS)
Deposited On:02 May 2011 15:53
Last Modified:02 May 2011 15:53

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

[1] Verpoorte R. Exploration of nature’s chemodiversity the role of secondary metabolites as leads in drug development. Drug Discovery Today. 1999;3: 232.

[2] Tripathi KD. Essential of Medical Pharmacology. New Delhi: Jayapee Brother Medical Publisher. 2003; 219.

[3] Kelly L. Essentials of Human physiology for pharmacy. CRC press pharmacy education series. 2005; 80.

[4] Chauhan Singh N. Medicinal and aromatic plants of Himachal Pradesh. 1988; 83.

[5] The Wealth of India, dictionary of raw materials and Industrial products raw Materials and Industrial products. Vol. 1(A). New Delhi: Council of scientific and Industrial Research, 1999; p 121.

[6] Kirtikar KR, Basu BD. Indian Medicinal Plants. Dehradun: Kirtikar KR, Basu BD (eds) International book distributors India. 1980; 2026.

[7] Prajapati Das N, Kumar T. A handbook of Medicinal Plants a complete source of book. India: Agrobis. 2003; 24.

[8] Chandel S, Bagai U. Antiplasmodial activity of Ajuga bracteosa against Plasmodium berghei infected BALB/c mice. Indian J Med Res. 2010; 131: 440.

[9] Collier HO, Dinneen LC, Johnson CA, Schneider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br Jr Pharmacol Chemther. 1968;32(2): 295.

[10] Vogel HG. Drug discovery and evaluation- Pharmacological assay. New York: Springer Villager Berlin Heidelberg. 2002; 149.

[11] Organization for Economic Cooperation and development. Paris, Guideline 423 for testing chemicals.2001; p 1.

[12] Deraedt R, Jouquey S, Delevallée F, Flahaut M. Release of prostaglandin E and F in an algogenic reaction and its inhibition. Eur J Pharmacol . 1980; 61(1):17.


Repository Staff Only: item control page