Neuroeconomics of suicide.

Takahashi, Ph.D Taiki (2011) Neuroeconomics of suicide. [Preprint]

Full text available as:

PDF - Draft Version


Suicidal behavior is a leading cause of injury and death worldwide. Suicide has been associated with psychiatric illnesses such as depression and schizophrenia, as well as economic uncertainty, and social/cultural factors. This study proposes a neuroeconomic framework of suicide. Neuroeconomic parameters (e.g., risk-attitude, probability weighting, time discounting in intertemporal choice, and loss aversion) are predicted to be related to suicidal behavior. Neurobiological and neuroendocrinological substrates such as serotonin, dopamine, cortisol (HPA axis), nitric oxide, serum cholesterol, epinephrine, norepinephrine, gonadal hormones (e.g., estradiol and progesterone), dehydroepiandrosterone (DHEA) in brain regions such as the orbitofrontal/dorsolateral prefrontal cortex and limbic regions (e.g., the amygdala) may supposedly be related to the neuroeconomic parameters modulating the risk of suicide. The present framework puts foundations for ―molecular neuroeconomics‖ of decision-making processes underlying suicidal behavior.

Item Type:Preprint
Keywords:Suicide, Neuroeconomics, risk, intertemporal choice, discounting
Subjects:Psychology > Behavioral Analysis
Neuroscience > Behavioral Neuroscience
Biology > Behavioral Biology
Psychology > Clinical Psychology
Psychology > Cognitive Psychology
Computer Science > Statistical Models
ID Code:7746
Deposited By: Takahashi, Ph.D Taiki
Deposited On:16 Dec 2011 00:09
Last Modified:16 Dec 2011 00:09

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

Akerlof GA, Kranton RE (2000) Economics and identity Quarterly Journal of Economics 115, 715-775

Asberg, M. Thoren, P. Traskman, L. Bertilsson L. and Ringberger, V. (1976) Serotonin depression‖—a biochemical subgroup within the affective disorders?, Science 191, 478–480.

Baca-Garcia E, Diaz-Sastre C, Ceverino A, Perez-Rodriguez MM, Navarro-Jimenez R, Lopez-Castroman J, Saiz-Ruiz J, de Leon J, Oquendo MA. (2010) Suicide attempts among women during low estradiol/low progesterone states. J Psychiatr Res. 44, 209-214.

Becker G. S. and Murphy K. A. Social Economics: Market Behavior in a Social Environment. Belknap Press of Harvard University Press (February 28, 2003)

Bowden, C. Theodorou, A. E. Cheetham, S. C. Lowther, S. Katona, C. L. Crompton M. R. and Horton, R.W. (1997) Dopamine D1 and D2 receptor binding sites in brain samples from depressed suicides and controls, Brain Res. 752, 227–233.

Butterfield M. I., Stechuchak K. M., Connor K. M., Davidson J. R., Wang C., MacKuen C. L., Pearlstein A. M., Marx C. E. Neuroactive steroids and suicidality in posttraumatic stress disorder. Am J Psychiatry. 2005 162, 380-382.

Cajueiro D.O. A note on the relevance of the q-exponential function in the context of intertemporal choices. Physica A 364 (2006) 385–388.

Cui H, Supriyanto I, Asano M, Ueno Y, Nagasaki Y, Nishiguchi N, Shirakawa O, Hishimoto A. (2010) A common polymorphism in the 3'-UTR of the NOS1 gene was associated with completed suicides in Japanese male population. Prog Neuropsychopharmacol Biol Psychiatry. 34, 992-996.

De Martino B, Camerer CF, Adolphs R. Amygdala damage eliminates monetary loss aversion. Proc Natl Acad Sci U S A. 107, 3788-3792.

Dombrovski AY, Szanto K, Siegle GJ, Wallace ML, Forman SD, Sahakian B, Reynolds CF 3rd, Clark L. (2011) Lethal Forethought: Delayed Reward Discounting Differentiates High- and Low-Lethality Suicide Attempts in Old Age. Biological Psychiatry (in press)

Dudley M, Goldney R, Hadzi-Pavlovic D. (2010) Are adolescents dying by suicide taking SSRI antidepressants? A review of observational studies. Australas Psychiatry. 18, 242-245.

Hamermesh, D.S., and Soss. N.M. (1974) ―An Economic Theory of Suicide,‖ Journal of Political Economy, pp. 83-98.

Iga J, Ueno S, Yamauchi K, Numata S, Tayoshi-Shibuya S, Kinouchi S, Nakataki M, Song H, Hokoishi K, Tanabe H, Sano A, Ohmori T. (2007) The Val66Met polymorphism of the brain-derived neurotrophic factor gene is associated with psychotic feature and suicidal behavior in Japanese major depressive patients. Am J Med Genet B Neuropsychiatr Genet. 144, 1003-1006.

Jia Z, Huang X, Wu Q, Zhang T, Lui S, Zhang J, Amatya N, Kuang W, Chan RC, Kemp GJ, Mechelli A, Gong Q. (2010) High-field magnetic resonance imaging of suicidality in patients with major depressive disorder. Am J Psychiatry. 167, 1381-13890.

Jollant F, Lawrence NS, Olie E, O'Daly O, Malafosse A, Courtet P, Phillips ML. (2010) Decreased activation of lateral orbitofrontal cortex during risky choices under uncertainty is associated with disadvantageous decision-making and suicidal behavior.

Neuroimage. 51, 1275-12781.

Kable JW, Glimcher PW. (2007) The neural correlates of subjective value during intertemporal choice. Nature Neuroscience. 10, 1625-1633.

Kahneman, D, and Tversky A. (1979) "Prospect Theory: An Analysis of Decision under Risk", Econometrica, XLVII, 263-291.

Kerkhof, A.J.F.M. Attempted suicide: patterns and trends. In: K. Hawton and K. van Heeringen, Editors, The International Handbook of Suicide and Attempted Suicide,

John Wiley & Sons Ltd., Chichester (2000), pp. 49–64.

Kunugi, H. Takei, N. Aoki H. and Nanko S., (1997) Low serum cholesterol in suicide attempters, Biol. Psychiatry 41, pp. 196–200.

Kunugi H, Urushibara T, Nanko S. (2004) Combined DEX/CRH test among Japanese patients with major depression. J Psychiatr Res. 38, 123-128.

Lempert KM, Pizzagalli DA. (2010) Delay discounting and future-directed thinking in anhedonic individuals. J Behav Ther Exp Psychiatry. 41, 258-264.

Marcotte, DE (2003) The economics of suicide, revisited. Southern Economic Journal, 69, 628-643.

Meana, J.J. Barturen F. and Garcia-Sevilla, J.A. (1992)Alpha 2-adrenoceptors in the brain of suicide victims: increased receptor density associated with major depression, Biol. Psychiatry 31, pp. 471–490.

McGowan, P.O. Sasaki, A. D’Alessio, A.C. Dymov, S. Labonte, B. Szyf, M. Turecki G. and Meaney, M.J. (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse, Nat. Neurosci. 12, pp. 342–348.

Mouri K, Hishimoto A, Fukutake M, Shiroiwa K, Asano M, Nagasaki Y, Ueno Y, Shirakawa O, Nishiguchi N, Maeda K. (2009) TPH2 is not a susceptibility gene for suicide in Japanese population. Prog Neuropsychopharmacol Biol Psychiatry. 33, 1546-1550.

Paulus MP, Frank LR (2006) Anterior cingulate activity modulates nonlinear decision weight function of uncertain prospects. Neuroimage. 30, 668-677.

Sakamoto S, Tanaka E, Neichi K, Sato K, Ono Y. (2006) Sociopsychological factors relating to suicide prevention in a Japanese rural community: coping behaviors and attitudes toward depression and suicidal ideation. Psychiatry Clin Neurosci. 60, 676-686.

Spoletini I, Piras F, Fagioli S, Rubino IA, Martinotti G, Siracusano A, Caltagirone C,

Spalletta G. (2011) Suicidal attempts and increased right amygdala volume in schizophrenia. Schizophr Res. 125, 30-40.

Suda A, Kawanishi C, Kishida I, Sato R, Yamada T, Nakagawa M, Hasegawa H, Kato D, Furuno T, Hirayasu Y. (2009) Dopamine D2 receptor gene polymorphisms are associated with suicide attempt in the Japanese population. Neuropsychobiology. 59, 130-134.

Supriyanto I, Sasada T, Fukutake M, Asano M, Ueno Y, Nagasaki Y, Shirakawa O, Hishimoto A. (2010) Association of FKBP5 gene haplotypes with completed suicide in the Japanese population. Prog Neuropsychopharmacol Biol Psychiatry. 35, 252-256.

Suzuki T (2008) Economic modelling of suicide under income uncertainty: For better understanding of middle-aged suicide. Australian Economic Papers, 47, 296-310.

Takahashi T, (2004) Cortisol levels and time-discounting of monetary gain in humans.

Neuroreport. 15, 2145-2147.

Takahashi T, Sakaguchi K, Oki M, Homma S, Hasegawa T. (2006) Testosterone levels and discounting delayed monetary gains and losses in male humans. NeuroEndocrinol Lett. 27, 439-444.

Takahashi, T. (2007) A comparison of intertemporal choices for oneself versus someone else based on Tsallis' statistics, Physica A 385, 637-644

Takahashi, T (2009) Theoretical frameworks for neuroeconomics of intertemporal choice. Journal of Neuroscience, Psychology, and Economics. 2(2), 75-90.

Takahashi, T (2011) Psychophysics of the probability weighting function. Physica A: Statistical Mechanics and its Applications 390, 902-905.

Takahashi T, Ono H, Radford MHB (2007a) Empirical estimation of consistency parameter in intertemporal choice based on Tsallis' statistics Physica A 381, 338-342

Takahashi T, Ikeda K, Fukushima H, Hasegawa T. (2007b) Salivary alpha-amylase levels and hyperbolic discounting in male humans. NeuroEndocrinol Lett. 28, 17-20.

Takahashi, T., Oono, H., Radford, M.H.B. (2008a) Psychophysics of time perception and intertemporal choice models. Physica A: Statistical Mechanics and its Applications 387, 2066-2074

Takahashi T, Oono H, Inoue T, et al. (2008b) Depressive patients are more impulsive and inconsistent in intertemporal choice behavior for monetary gain and loss than healthy subjects - An analysis based on Tsallis' statistics, NeuroEndocrinology Letters, 29, 351-358

Takahashi T, Shinada M, Inukai K, Tanida S, Takahashi C, Mifune N, Takagishi H, Horita Y, Hashimoto H, Yokota K, Kameda T, Yamagishi T. (2010) Stress hormones predict hyperbolic time-discount rates six months later in adults. NeuroEndocrinology Letters, 31, 616-621.

Tversky, A and Kahneman D (1992). "Advances in prospect theory: Cumulative representation of uncertainty". Journal of Risk and Uncertainty 5: 297–323.

Prelec D. (1998). The probability weighting function. Econometrica 60. 497-528.

van Heeringen, C, Audenaert, K. Van Laere, K. Dumont, F. Slegers, G. Mertens J. and Dierckx, R.A. (2003) Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide, J. Affect. Disord. 74, 149–158.

van Heeringen C, Bijttebier S, Godfrin K. (2011) Suicidal brains: a review of functional and structural brain studies in association with suicidal behaviour. Neurosci Biobehav Rev. 35, 688-698.

Xu L, Liang ZY, Wang K, Li S, Jiang T. Neural mechanism of intertemporal choice: from discounting future gains to future losses. Brain Res. 2009 1261:65-74.

Yamasaki A, Sakai R, Shirakawa T. (2005) Low income, unemployment, and suicide mortality rates for middle-age persons in Japan. Psychol Rep. 96, 337-348.

Yanagi M, Shirakawa O, Kitamura N, Okamura K, Sakurai K, Nishiguchi N, Hashimoto T, Nushida H, Ueno Y, Kanbe D, Kawamura M, Araki K, Nawa H, Maeda K. (2005)

Association of 14-3-3 epsilon gene haplotype with completed suicide in Japanese. J Hum Genet. 50, 210-216.

Zhong S, Israel S, Xue H, Sham PC, Ebstein RP, Chew SH. (2009) A neurochemical approach to valuation sensitivity over gains and losses. Proc Biol Sci. 276, 4181-4188.


Repository Staff Only: item control page