Blood Transfusions: Are They Life Saving or Transfusing Infections?

Amrutha Kumari, B and Deepa, S and Venkatesha, D (2011) Blood Transfusions: Are They Life Saving or Transfusing Infections? [Journal (On-line/Unpaginated)]

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Introduction: There is a risk of 1 - 2 per 1000 recipients receiving contaminated blood with viral, bacterial and parasitic agents.TTI’S are the most commonly encountered complications in transfusion medicine. The objective of the study was to determine the seroprevalence of TTI’s among blood donors, who represent healthy population at large. Materials & methods: A total of 33,658 blood units were received from voluntary and replacement donors over a period of 5 years. Surface antigen of HBV and antibodies to HIV and HCV were determined using ELISA. Syphilis was detected using TPHA test. Results: 947 (2.81%) blood units tested positive for HBV, HCV, HIV and / or syphilis. Overall prevalence was HBV – 1.77%, HCV – 0.13%, HIV – 0.63% and Syphilis – 0.28%. Nine (0.03%) donors had coinfections. Conclusion: The screening of blood donors is the corner stone in assuring the safety of blood transfusion.

Item Type:Journal (On-line/Unpaginated)
Keywords:Transfusion Transmitted Infections; HBV; HCV; HIV; Syphilis
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:7963
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:09 Nov 2012 17:37
Last Modified:09 Nov 2012 17:37

References in Article

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1. Mahmud Z. Are the blood transfusions safe! JAFMC June 2009;5(1):1-2.

2. Choudary N. Transfusion Transmitted Infections: How many more? Asian J Transfus Sci July 2010;4(2):71-72. Available at

3. Olokaba AB, Salawu FK, Danburam A et al. Viral Hepatitides in Voluntary Blood Donors in Yola, Nigeria. Europ J Sci Res 2009;31(3):329-334.

4. Afsar I, Gungor S, Sener AG et al. The prevalence of HBV, HCV and HIV infections among blood donors in Izmir, Turkey. Indian J Med Microbiol 2008;26:288-289.

5. World Health Organization 2010. Screening Donated Blood For Transfusion Transmissible Infections: Recommendations. WHO; Geneva. 2010. Available at

6. Panda M, Kar K. HIV, hepatitis B and C infection status of the blood donors in a blood bank of a tertiary health care centre of Orissa. Indian J Public Health 2008;52:43-44.

7. Pahuja S, Sharma M, Baitha B, Jain M. Prevalence and trends of markers of hepatitis C virus, hepatitis B virus and human immunodeficiency virus in Delhi blood donors: a hospital based study. Jpn J Infect Dis 2007;60:389-391.

8. Singh K, Bhat S, Shastry S. Trend in Seroprevalence of Hepatitis B Virus Infection among Blood Donors of Coastal Karnataka, India. J Infect Dev Ctries May 2009;3(5):376-379. Available at

9. Garg S, Mathur DR, Garg DK. Comparison of seropositivity of HIV, HBV, HCV and syphilis in replacement and voluntary blood donors in western India. Indian J Pathol Microbiol 2001;44:409-412.

10. Bhattacharya P, Chandra PK, Datta S et al. Significant Increase in HBV, HCV, HIV & Syphilis Infections Among Blood Donors in West Bengal, Eastern India 2004-2005: Exploratory Screening Reveals High Frequency of Occult HBV infection. World J Gastroenterol July 2007;13(27):3730-3733.

11. Khaja MN, Madhavi C, Thippa Vazzula R et al. High prevalence of hepatitis C Virus infection and Genotype Distribution Among General Population, Blood Donors & Risk Groups. J infect Genet Evol May 2006;6(3):198-204.

12. Sabharwal ER, Langer S. prevalence and trends of seroprevalence of HIV & syphilis in blood donors of Delhi. Indian J Practising Doctor 2008;5(3):1-3.

13. Nanu A, Sharma SP, Chaterjee K, Jyothi P. Markers for transfusion- transmissible infection in North Indian voluntary and replacement donors : prevalence and trends 1989-1996. Vox Sanguinis 1997;73:70-73 (s)

14. Kaur G, Basu S, Kaur R et al. Patterns of infections among blood donors in a tertiary care centre: A retrospective study. Natl Med J India 2010;23(30):147–149.

15. Punde RP, Bhargava A, Varshney S et al. Ascertaining the prevalence of occult HBV infection in voluntary blood donors: A study from Central India. Indian J path Microbiol 2011;54:408

16. Editorial. Improving Blood Safety Worldwide. Lancet. 2007:370(9603):1879-1974.

17. Meena M, Jindal T, Hazarika A. Prevalence of HBV & HCV among blood donors at a tertiary care hospital in India: A five year study. Transfusion 2011;51:198-202.


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