Borderline Ovarian Malignancies : A Single Institute Retrospective Study.

Kundargi, R and Guruprasad, B and Shakuntala, PN and Rathod, R and Bhise, R and Shobha, K and Pallavi, R and Umadevi, K and Bafna, UD (2013) Borderline Ovarian Malignancies : A Single Institute Retrospective Study. [Journal (On-line/Unpaginated)]

Full text available as:

PDF - Published Version
Available under License Creative Commons Attribution No Derivatives.



Background: Borderline ovarian tumors are histologically characterized as epithelial tumors with a stratified growth pattern but without destructive stromal invasion. Little is known about the histological subtypes and outcome, role of fertility sparing surgery and role of postoperative therapy in advanced stage in Indian scenario. While there is ample data in the world literature about this disease, prognosis in Indian patients is largely unknown due to dearth of studies in our setting. Objective: To study the demographic profile, clinical features, imaging, treatment and outcome of borderline ovarian tumors. Methods: This is a retrospective study of eighty seven patients with pathologically proven diagnosis of borderline ovarian tumor, diagnosed and treated from January 2006 to October 2011 at our institution. Most patients underwent surgical staging which incuded total abdominal hysterectomy and bilateral salphingo-oophorectomy, infracolic omentectomy, bilateral pelvic and para aortic lymphadenectomy. Young patients who had not completed their family underwent fertility sparing surgery. Patients with invasive metastatic implants received adjuvant chemotherapy. The outcome of these patients was correlated with stage, type of peritoneal implant, type of surgical procedure and with histological subtype. Results: At a median follow-up of 48 months, 100 percent survival was noted. One patient with stage III disease had recurrence. Conclusions: Borderline ovarian tumors occur at a younger age compared to invasive tumors. In patients with early stage disease who wish to preserve fertility, hysterectomy and contralateral oophorectomy are not necessary. Serous tumors occur at a younger age. They can be associated with invasive peritoneal implants and raised CA125 values. Majority of the serous tumors are bilateral and smaller in size compared to mucinous and endometroid tumors. Raised CA125 values did not correlate with the stage of disease. These patients have an excellent prognosis even in Indian scenario where majority of patients present with big ovarian masses.

Item Type:Journal (On-line/Unpaginated)
Keywords:Borderline ovarian tumor; Retrospective study; CA125
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:8933
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:04 May 2013 23:09
Last Modified:04 May 2013 23:09

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Taylor HC Jr: Malignant and semimalignant tumors of the ovary. Surg Gynecol Obstet 1929, 48:204-230.

2. Skírnisdóttir I, Garmo H, Wilander E, Holmberg L. Borderline ovarian tumors in Sweden 1960-2005: trends in incidence and age at diagnosis compared to ovarian cancer. Int J Cancer. 2008 Oct 15;123(8):1897-1901.

3. Levi F, Vecchia C L, Randimbison L and Te VC. Borderline ovarian tumours in Vaud, Switzerland: incidence, survival and second neoplasms British Journal of Cancer 1999;79(1):4–6

4. Attanucci CA, Ball HG, Zweizig SL, Chen AH. Differences in symptoms between patients with benign and malignant ovarian neoplasms. Am J of Obstet Gynecol 2004 May;190(5):1435-1437

5. Priya C, Kumar S, Kumar L. Borderline ovarian tumours : An update. Indian J Med Paediatr Oncol 2008;29:19-27

6. Vanleeuwen FE, Klip H, Mooij TM, Swaluw AMG, Lambalk CB, Kortman M, et al. Risk of borderline and invasive ovarian tumours after ovarian stimulation for in vitro fertilization in a large Dutch cohort. Hum Reprod2011;26(12):3456–3465.

7. Morotti M, Menada MV, Gillott DJ, Venturini PL, Ferrero S. The preoperative diagnosis of borderline ovarian tumors: a review of current literature. Arch Gynecol Obstet. 2012;285(4):1103-1112.

8. Song T, Choi CH, Park HS, Kim MK, Lee YY, Kim TJ et al. Fertility-sparing surgery for borderline ovarian tumors: oncologic safety and reproductive outcomes. Int J Gynecol Caner 2011, May;21(4):640-646.

9. Park JY, Kim DY, Kim JH, Kim YM, Kim YT, Nam JH. Surgical management of borderline ovarian tumors: The role of fertility-sparing surgery. Gynecol Oncol. 2009 Apr;113(1):75-82.

10. Park JY, Kim DY, Kim JH, Kim YM, Kim KR, Kim YT, et al. Micropapillary pattern in serous borderline ovarian tumors: does it matter? Gynecol Oncol. 2011 Dec;123(3):511-516.

11. Morice P, Uzan C, Fauvet R, Gouy S, Duvillard P, Darai E. Borderline ovarian tumour: pathological diagnostic dilemma and risk factors for invasive or lethal recurrence. Lancet Oncol. 2012 Mar;13(3):e103-115.

12. Riopel MA, Ronnett BM, Kurman RJ. Evaluation of diagnostic criteria and behavior of ovarian intestinal-type mucinous tumors: atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas. Am J Surg Pathol. 1999 Jun;23(6):617-635.

13. Chambers JT. Borderline ovarian tumors: a review of treatment. Yale J Biol Med. 1989 Jul-Aug; 62(4): 351–365.


Repository Staff Only: item control page