Metastatic Renal Cell Carcinoma in the Sinonasal Region

Raj, JA and Mahantachar, V and Rajaram, T (2013) Metastatic Renal Cell Carcinoma in the Sinonasal Region. [Journal (On-line/Unpaginated)]

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Sinonasal region is an exceptional site for metastatic tumors. Renal cell carcinoma is known to metastasise to the most unusual sites, the sinonasal region being one of them. Clear cell carcinoma is its most common histologic variant. A sixty year old male presented with epistaxis and nasal obstruction. Clinical examination and CT scan revealed a vascular tumor in the right nasal cavity and maxillary sinus. The tumor was resected and sent for histopathological examination. A diagnosis of metastatic clear cell renal cell carcinoma was made and confirmed with immunohistochemistry (IHC). The pathologic diagnosis was made without prior knowledge of the primary tumor in the kidney. Very few cases of metastatic renal cell carcinoma in the sinonasal region have been reported in literature. We present this case to document its occurrence, highlight the rarity and briefly discuss the differential diagnoses of clear cell carcinoma in the sinonasal area, based on morphology and IHC.

Item Type:Journal (On-line/Unpaginated)
Keywords:Sinonasal region; Metastatic renal cell carcinoma; Diagnosis
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:9167
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:25 Feb 2014 12:42
Last Modified:25 Feb 2014 12:42

References in Article

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1. Bechara GR, Resende Junior JAD, Gouveia HA, et al. Metastasis to paranasal sinuses as the first presenting sign of renal cell carcinoma. Open Journal of Urology. 2012;2: 28-31.

2. Nasab MS, Jafari M, Bahar SHM, et al. Endoscopic management of unusual metastasis of renal cell carcinoma to the sinonasal area. Acta Medica Iranica. 2009;47(5):419-421.

3. Terada T. Renal cell carcinoma metastatic to the nasal cavity. Int J Clin Exp Pathol. 2012;5(6):588-591.

4. Sountoulides P, Metaxa L, Cindolo L. Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports. Journal of Medical Case Reports.2011;5:429. Available at

5. Fyrmpas G, Adeniyi A, Baer S. Occult renal cell carcinoma manifesting with epistaxis in a woman: a case report. Journal of Medical Case Reports. 2011;5:79. Available at

6. Kaminski B, Kobirorska-Novak J, Bien S. Distant metastasis to nasal cavities and paranasal sinuses, from the organs outside the Head and Neck. The Polish Otolaryngology. 2008; 62(4): 422-425.

7. Ziari M, Shen S, Amaro RJ, et al. Metastatic renal cell carcinoma to the nose and ethmoid sinus. Urology 2006;67:199.

8. Amin MB, Tamboli P, Javidan J, et al. Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: an experience of 405 cases. Am J Surg Pathol.2002;26:281-291.

9. Eble JN, Young RH. Tumors of the urinary tract. (Chapter 12, vol 1). In Fletcher CDM, editor. Diagnostic histopathology of tumors, 3rd ed. Philadelphia, USA: Churchill Livingstone (Elsevier); 2007. p 494

10. Negahban S, Daneshbod Y, Khademi B, et al. Sinonasal Clear Cell Adenocarcinoma: A case report. Acta Cytol. 2009;53:597-600.

11. Storck K, Moh'd Hadi U, Simpson R, et al. Sinonasal renal cell-like adenocarcinoma: A report on four patients. Head Neck Pathol. 2008 June;2(2):75-80.

12. Custodio S, Joaquim A, Peixoto V, et al. Metastatic renal cell carcinoma: The importance of immunohistochemistry in differential diagnosis. Case Rep Oncol. 2012 Jan-Apr;5(1):30-34.


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