?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=A+left+temporal+lobe+impairment+of+auditory+information+processing+in+schizophrenia%3A+an+event-related+potential+study&rft.creator=Schall%2C+U.&rft.creator=Sch%C3%B6n%2C+A.&rft.creator=Zerbin%2C+D.&rft.creator=Bender%2C+S.&rft.creator=Eggers%2C+C.&rft.creator=Oades%2C+R.+D.&rft.subject=Neuropsychiatry&rft.description=Introduction%3A+A+measure+of+auditory+prepulse+inhibition+(PPI)+or+sensory+gating+is+the+reduction+of+the+scalp-recorded+P1+event-related+potential+(ERP)+after+a+sound+that+is+preceded+by+100-300+ms+by+a+click+as+prepulse.+This+measure+of+sensory+gating+was+adapted+to+study+the+effect+of+a+prepulse+on+processing+tones+that+were+part+of+a+%22Go%2Fno-go%22+discrimination.+%0A%0AMethods%3A+ERPs+were+recorded+at+right+and+left+frontal+and+temporal+sites+on+the+scalp+of+groups+of+patients+with+schizophrenia+(SCH%2C+8)%2C+obsessive+compulsive+disorder+(OCD%2C+10)+and+healthy+controls+(CON%2C+19).+%0A%0AResults%3A+%0Aa)+Both+patient+groups+responded+slower+and+showed+more+errors+of+omission+than+controls.%0Ab)+A+prepulse+presented+100+ms+(but+not+at+500+ms)+before+either+tone+reduced+the+P1+or+P50+ERP+amplitude+on+healthy+controls%2C+but+showed+a+right+temporal+shift+in+the+SCH+patients.%0Ac)+If+the+tone+was+the+'no-go'+stimulus+in+the+tone+discrimination+the+prepulse+reduced+the+N1+amplitude+in+both+normal+controls+and+SCH+patients.+This+N100+amplitude+was+similar+in+records+from+over+the+left+and+right+hemisphere+of+controls+but+was+shifted+to+right+temporal+sites+in+the+SCH+group.%0Ad)+OCD+patients+showed+a+relative+predominance+of+the+left+hemisphere+in+the+gating+of+frontal+P1%2C+N100+and+P300+components%2C+but+early+gating+was+not+significantly+impaired+in+this+group.+%0A%0AConclusions%3A+These+results+show+a+reduction+of+a+PPI-like+effect+on+early+processing+(e.g.+P50%2FP1)+that+is+more+marked+in+the+left+hemisphere+of+SCH+patients%2C+and+may+affect+channel+selection+for+processing+information+about+task-relevant+sounds+(e.g.+N100)+%0A&rft.publisher=Elsevier&rft.date=1997&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1156%2F2%2FNeuro-letter.pdf&rft.identifier=++Schall%2C+U.+and+Sch%C3%B6n%2C+A.+and+Zerbin%2C+D.+and+Bender%2C+S.+and+Eggers%2C+C.+and+Oades%2C+R.+D.++(1997)+A+left+temporal+lobe+impairment+of+auditory+information+processing+in+schizophrenia%3A+an+event-related+potential+study.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1156%2F