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"Locomotor activity in relation to dopamine and noradrenaline in the nucleus accumbens, septal and frontalk areas: a 6-hydroxydopamine study"^^ .
"The Study and the Method: \nThe locomotor activity of adult male Sprague-Dawley was automatically recorded in a circular corridor - circadian changes are described as well as the response to the novel situation and its habituation over three hours.\nFour groups of animals were compared, - those with sham/vehicle operations and those with 6-OHDA dopamine (DA) depleting lesions in - \nthe frontal cortex,\nthe limbic septum, and\nthe ventral tegmental area (VTA - A10). \n\nResults: \n1/ Lesions of the VTA resulted in increased dark-phase activity, - and a large response to an apomorphine challenge in comparison to other lesion and control groups:\n2/ Septal 6-OHDA lesions did not alter locomotion:\n3/ After frontal DA depletion there was a small increase of locomotion after the apomorphine challenge, that might reflect increased receptor sensitivity in cortical or sub-cortical areas:\n(Table 1: HPLC measures of NA, DA and DOPAC for each group in the prefrontal cortex, septum and N. accumbens) \n\nFigure 1 illustrates the cumulative photocell counts per hour over 24 hours for the 4 groups:.\nFigure 2 illustrates the cumulative photocell counts every 10 minutes over 90 minutes post-apomorphine treatment - maximal at 20-30 minutes and habituating over 60 minutes (90 minutes for the VTA group): overall activity VTA >> Frontal > Septal > Controls.\n\nConclusions:\nAlong with correlations found for motor activity with cortical levels of DA and NA, these results are interpreted to support a role for DA, NA and the region of the frontal cortex in modulating locomotion that is primarily mediated by mesolimbic VTA - accumbens - DA activity.\n"^^ .
"1986" .
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"16" .
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"S.Karger"^^ .
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"Neuropsychobiology"^^ .
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"H."^^ .
"Simon"^^ .
"H. Simon"^^ .
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"R.D."^^ .
"Oades"^^ .
"R.D. Oades"^^ .
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"M."^^ .
"Le Moal"^^ .
"M. Le Moal"^^ .
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"K."^^ .
"Taghzouti"^^ .
"K. Taghzouti"^^ .
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"J-M."^^ .
"Rivet"^^ .
"J-M. Rivet"^^ .
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"Locomotor activity in relation to dopamine and noradrenaline in the nucleus accumbens, septal and frontalk areas: a 6-hydroxydopamine study (PDF)"^^ .
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"rat-npb-86.pdf"^^ .
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"HTML Summary of #1372 \n\nLocomotor activity in relation to dopamine and noradrenaline in the nucleus accumbens, septal and frontalk areas: a 6-hydroxydopamine study\n\n" .
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"Behavioral Neuroscience" .
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"Behavioral Biology" .
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"Neuropharmacology" .
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"Psychobiology" .
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