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abstract: |
The Study and the Method:
The locomotor activity of adult male Sprague-Dawley was automatically recorded in a circular corridor - circadian changes are described as well as the response to the novel situation and its habituation over three hours.
Four groups of animals were compared, - those with sham/vehicle operations and those with 6-OHDA dopamine (DA) depleting lesions in -
the frontal cortex,
the limbic septum, and
the ventral tegmental area (VTA - A10).
Results:
1/ Lesions of the VTA resulted in increased dark-phase activity, - and a large response to an apomorphine challenge in comparison to other lesion and control groups:
2/ Septal 6-OHDA lesions did not alter locomotion:
3/ After frontal DA depletion there was a small increase of locomotion after the apomorphine challenge, that might reflect increased receptor sensitivity in cortical or sub-cortical areas:
(Table 1: HPLC measures of NA, DA and DOPAC for each group in the prefrontal cortex, septum and N. accumbens)
Figure 1 illustrates the cumulative photocell counts per hour over 24 hours for the 4 groups:.
Figure 2 illustrates the cumulative photocell counts every 10 minutes over 90 minutes post-apomorphine treatment - maximal at 20-30 minutes and habituating over 60 minutes (90 minutes for the VTA group): overall activity VTA >> Frontal > Septal > Controls.
Conclusions:
Along with correlations found for motor activity with cortical levels of DA and NA, these results are interpreted to support a role for DA, NA and the region of the frontal cortex in modulating locomotion that is primarily mediated by mesolimbic VTA - accumbens - DA activity.
altloc:
- http://www.biopsychology.uni-essen.de/Rat-NPB-loco-1986.htm
chapter: ~
commentary: ~
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creators_name:
- family: Oades
given: R.D.
honourific: ''
lineage: ''
- family: Taghzouti
given: K.
honourific: ''
lineage: ''
- family: Rivet
given: J-M.
honourific: ''
lineage: ''
- family: Simon
given: H.
honourific: ''
lineage: ''
- family: Le Moal
given: M.
honourific: ''
lineage: ''
date: 1986
date_type: published
datestamp: 2001-03-16
department: ~
dir: disk0/00/00/13/72
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eprint_status: archive
eprintid: 1372
fileinfo: /style/images/fileicons/application_pdf.png;/1372/2/rat%2Dnpb%2D86.pdf
full_text_status: public
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keywords: 'locomotion, noradrenaline, NA, dopamine, DA, DOPAC, accumbens, septum, frontal cortex, mesolimbic, mesocortical ventral tegmental area, VTA, circadian rhythm, novelty, apomorphine, habituation, rat'
lastmod: 2011-03-11 08:54:36
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: ~
pagerange: 37-42
pubdom: TRUE
publication: Neuropsychobiology
publisher: S.Karger
refereed: TRUE
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relation_type: []
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reportno: ~
rev_number: 10
series: ~
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status_changed: 2007-09-12 16:37:33
subjects:
- behav-neuro-sci
- bio-behav
- neuro-pharm
- psy-bio
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: 'Locomotor activity in relation to dopamine and noradrenaline in the nucleus accumbens, septal and frontalk areas: a 6-hydroxydopamine study'
type: journalp
userid: 1054
volume: 16