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--- abstract: | The Study and the Method: The locomotor activity of adult male Sprague-Dawley was automatically recorded in a circular corridor - circadian changes are described as well as the response to the novel situation and its habituation over three hours. Four groups of animals were compared, - those with sham/vehicle operations and those with 6-OHDA dopamine (DA) depleting lesions in - the frontal cortex, the limbic septum, and the ventral tegmental area (VTA - A10). Results: 1/ Lesions of the VTA resulted in increased dark-phase activity, - and a large response to an apomorphine challenge in comparison to other lesion and control groups: 2/ Septal 6-OHDA lesions did not alter locomotion: 3/ After frontal DA depletion there was a small increase of locomotion after the apomorphine challenge, that might reflect increased receptor sensitivity in cortical or sub-cortical areas: (Table 1: HPLC measures of NA, DA and DOPAC for each group in the prefrontal cortex, septum and N. accumbens) Figure 1 illustrates the cumulative photocell counts per hour over 24 hours for the 4 groups:. Figure 2 illustrates the cumulative photocell counts every 10 minutes over 90 minutes post-apomorphine treatment - maximal at 20-30 minutes and habituating over 60 minutes (90 minutes for the VTA group): overall activity VTA >> Frontal > Septal > Controls. Conclusions: Along with correlations found for motor activity with cortical levels of DA and NA, these results are interpreted to support a role for DA, NA and the region of the frontal cortex in modulating locomotion that is primarily mediated by mesolimbic VTA - accumbens - DA activity. altloc: - http://www.biopsychology.uni-essen.de/Rat-NPB-loco-1986.htm chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: [] creators_name: - family: Oades given: R.D. honourific: '' lineage: '' - family: Taghzouti given: K. honourific: '' lineage: '' - family: Rivet given: J-M. honourific: '' lineage: '' - family: Simon given: H. honourific: '' lineage: '' - family: Le Moal given: M. honourific: '' lineage: '' date: 1986 date_type: published datestamp: 2001-03-16 department: ~ dir: disk0/00/00/13/72 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 1372 fileinfo: /style/images/fileicons/application_pdf.png;/1372/2/rat%2Dnpb%2D86.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'locomotion, noradrenaline, NA, dopamine, DA, DOPAC, accumbens, septum, frontal cortex, mesolimbic, mesocortical ventral tegmental area, VTA, circadian rhythm, novelty, apomorphine, habituation, rat' lastmod: 2011-03-11 08:54:36 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: ~ pagerange: 37-42 pubdom: TRUE publication: Neuropsychobiology publisher: S.Karger refereed: TRUE referencetext: ~ relation_type: [] relation_uri: [] reportno: ~ rev_number: 10 series: ~ source: ~ status_changed: 2007-09-12 16:37:33 subjects: - behav-neuro-sci - bio-behav - neuro-pharm - psy-bio succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: 'Locomotor activity in relation to dopamine and noradrenaline in the nucleus accumbens, septal and frontalk areas: a 6-hydroxydopamine study' type: journalp userid: 1054 volume: 16