?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Plasma+neuropeptide-Y+levels%2C+monoamine+metabolism%2C+electrolyte+excretion+and+drinking+behavior+in+children+with+attention-deficit+hyperactivity+disorder&rft.creator=Oades%2C+R.D.&rft.creator=Daniels%2C+R.&rft.creator=Rascher%2C+W.&rft.subject=Neurochemistry&rft.subject=Neuropsychiatry&rft.subject=Physiological+Psychology&rft.description=Introduction%3A+This+study+was+conducted+against+a+background+of+the+following+four+points%3A+a)+increased+drinking+behavior+in+children+with+attention-deficit+hyperactivity+disorder+(ADHD)%2C+b)+the+parallel+between+some+behaviours+associated+with+ADHD+and+with+hypertension%2C+c)+the+use+of+the+spontaneously+hypertensive+rat+as+a+model+for+ADHD%2C+and+d)+similarities+in+the+changes+of+neuropeptide-Y+(NPY)+and+catecholamine+in+the+studies+of+hypertension+and+drinking%2C+%0A%0AMethods%3A+Measures+of+NPY%2C+catecholamines+and+electrolyte+balance+were+compared+in+the+plasma+and+urine+of+healthy+children+and+those+with+ADHD.+Drinking+was+monitored+during+three+hours+of+neuropsychological+tests+over+two+days+in+14+ADHD+(mean+9.8+years-of-age)+and+9+healthy+children+(10.6+years-of-age).+%0A%0AResults%3A+%0APatients+drank+4+times+more+water+and+showed+twice+the+levels+of+NPY+in+controls.+In+controls+there+were+positive+and+in+patients+there+were+negative+relationships+for+NPY+with+drinking+and+restless+behavior.+%0APatients'+plasma+levels+of+norepinephrine+(NE)+and+epinephrine+were+slightly+elevated%2C+but+urinary+levels+of+NE+and+the+serotonin+metabolite+were+markedly+increased.+Urinary+excretion+rates+for+sodium+(not+potassium)%2C+phosphate+and%2C+especially+calcium+were+decreased+in+patients.+NPY+levels+were+inversely+related+to+calcium+excretion+and+drinking+inversely+to+sodium+circulating+(but+positively+with+potassium+and+phosphate+excretion).+%0A%0AConclusions%3A+Increases+of+drinking+and+increased+levels+of+circulating+NPY+in+ADHD+children+and+decreased+electrolyte+excretion+may+reflect+a+common+disturbance+in+the+homeostatic+control+of+metabolism.This+may+contribute+to+the+impairments+of+attentional+and+behavioural+control+typical+of+ADHD+children.+%0A%0A&rft.publisher=Elsevier&rft.date=1998&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1418%2F2%2Fadhd-npy-98.pdf&rft.identifier=++Oades%2C+R.D.+and+Daniels%2C+R.+and+Rascher%2C+W.++(1998)+Plasma+neuropeptide-Y+levels%2C+monoamine+metabolism%2C+electrolyte+excretion+and+drinking+behavior+in+children+with+attention-deficit+hyperactivity+disorder.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1418%2F