This site has been permanently archived. This is a static copy provided by the University of Southampton.
<> "The repository administrator has not yet configured an RDF license."^^ .
<> .
.
"Dopamine-sensitive alternation and collateral behaviour in a Y-maze: effects of d-amphetamine and haloperidol"^^ .
"Introduction: \nThe frequency of spontaneous alternation in a Y-maze (visiting each arm in turn at p>50%) depends on the influence of the attention given to intra- and extra-maze cues. \nWe examined the observing responses shown by rats (collateral rearing and head-turning behaviour), the habituation to the novelty and alternation responses over 15 minutes/day, four days in a row - in a Y-maze under enhanced and reduced dopamine (DA) activity (amphetamine- and haloperidol treatment).\nMethods:\nPrior to placement in a Y-maze for 15 minutes observation on 4 successive days animals were treated with either amphetamine (0.5 or 2.5 mg/kg) or pre-treated with a low dose of haloperidol (0.08 mg/kg, ip).\nResults: \n1/ Amphetamine treated animals chose the arms at random on day 1, but after the higher dose on day 2-4 they perseverated their choice. The controls maintained their alternation over this period.\n2/ The amphetamine-induced effects on alternation were prevented by prior treatment with the neuroleptic haloperidol.\n3/ Amphetamine treatment increased the frequency of rearing in the middle at the choice point of the Y-maze. Haloperidol pre-treatment blocked this increase at the midpoint on day 1, and blocked the rearing behavior at the end of an arm on day 2.\n4/ Amphetamine also increased the frequency of head turning and \"looking\", - an effect that was also prevented by haloperidol. (day 2 onwards).\n5/ Haloperidol increased the duration of\" looking\" and of rearing at the end of an arm later in testing.. \nConclusions:\nTwo effects are postulated to have occurred.\na) a conflict on day 1 between the novelty-controlled sensory or attentional effects, that leads to an alternation of arm-choice, and amphetamine-induced DA activity that facilitates an alternation of behavioural responses: -- the result was random choice and increased rearing at the choice point.\nb) On days 2-4 the drug-induced effects on switching motor responses came to control behaviour \n"^^ .
"1985" .
.
"85" .
.
"Springer-Verlag"^^ .
.
.
"Psychopharmacology"^^ .
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
.
"H."^^ .
"Simon"^^ .
"H. Simon"^^ .
.
"R.D."^^ .
"Oades"^^ .
"R.D. Oades"^^ .
.
"K."^^ .
"Taghzouti"^^ .
"K. Taghzouti"^^ .
.
"M."^^ .
"Le Moal"^^ .
"M. Le Moal"^^ .
.
.
.
.
.
"Dopamine-sensitive alternation and collateral behaviour in a Y-maze: effects of d-amphetamine and haloperidol (PDF)"^^ .
.
.
.
.
.
"rat-amph-85.pdf"^^ .
.
"HTML Summary of #1435 \n\nDopamine-sensitive alternation and collateral behaviour in a Y-maze: effects of d-amphetamine and haloperidol\n\n" .
"text/html" .
.
.
"Behavioral Neuroscience" .
.
.
"Behavioral Biology" .
.
.
"Neuropharmacology" .
.
.
"Physiological Psychology" .
.
.
"Psychobiology" .
.