TY  - GEN
ID  - cogprints1435
UR  - http://cogprints.org/1435/
A1  - Oades, R.D.
A1  - Taghzouti, K.
A1  - Simon, H.
A1  - Le Moal, M.
Y1  - 1985///
N2  - Introduction: 
The frequency of spontaneous alternation in a Y-maze (visiting each arm in turn at p>50%) depends on the influence of the attention given to intra- and extra-maze cues. 
We examined the observing responses shown by rats (collateral rearing and head-turning behaviour), the habituation to the novelty and alternation responses over 15 minutes/day, four days in a row - in a Y-maze under enhanced and reduced dopamine (DA) activity (amphetamine- and haloperidol treatment).
Methods:
Prior to placement in a Y-maze for 15 minutes observation on 4 successive days animals were treated with either amphetamine (0.5 or 2.5 mg/kg) or pre-treated with a low dose of haloperidol (0.08 mg/kg, ip).
Results: 
1/ Amphetamine treated animals chose the arms at random on day 1, but after the higher dose on day 2-4 they perseverated their choice. The controls maintained their alternation over this period.
2/ The amphetamine-induced effects on alternation were prevented by prior treatment with the neuroleptic haloperidol.
3/ Amphetamine treatment increased the frequency of rearing in the middle at the choice point of the Y-maze. Haloperidol pre-treatment blocked this increase at the midpoint on day 1, and blocked the rearing behavior at the end of an arm on day 2.
4/ Amphetamine also increased the frequency of head turning and "looking", - an effect that was also prevented by haloperidol. (day 2 onwards).
5/ Haloperidol increased the duration of" looking" and of rearing at the end of an arm later in testing.. 
Conclusions:
Two effects are postulated to have occurred.
a) a conflict on day 1 between the novelty-controlled sensory or attentional effects, that leads to an alternation of arm-choice, and amphetamine-induced DA activity that facilitates an alternation of behavioural responses: -- the result was random choice and increased rearing at the choice point.
b) On days 2-4 the drug-induced effects on switching motor responses came to control behaviour 

PB  - Springer-Verlag
KW  - dopamine
KW  -  DA
KW  -  amphetamine
KW  -  haloperidol
KW  -  Y-maze
KW  -  alternation
KW  -  rearing
KW  -  collateral behaviour
KW  -  switching
KW  -  novelty
KW  -  attention
KW  -  grooming
KW  -  locomotion
KW  -  rat
KW  -  observing-response
TI  - Dopamine-sensitive alternation and collateral behaviour in a Y-maze: effects of d-amphetamine and haloperidol
SP  - 123
AV  - public
EP  - 128
ER  -

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