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abstract: |
Introduction:
The frequency of spontaneous alternation in a Y-maze (visiting each arm in turn at p>50%) depends on the influence of the attention given to intra- and extra-maze cues.
We examined the observing responses shown by rats (collateral rearing and head-turning behaviour), the habituation to the novelty and alternation responses over 15 minutes/day, four days in a row - in a Y-maze under enhanced and reduced dopamine (DA) activity (amphetamine- and haloperidol treatment).
Methods:
Prior to placement in a Y-maze for 15 minutes observation on 4 successive days animals were treated with either amphetamine (0.5 or 2.5 mg/kg) or pre-treated with a low dose of haloperidol (0.08 mg/kg, ip).
Results:
1/ Amphetamine treated animals chose the arms at random on day 1, but after the higher dose on day 2-4 they perseverated their choice. The controls maintained their alternation over this period.
2/ The amphetamine-induced effects on alternation were prevented by prior treatment with the neuroleptic haloperidol.
3/ Amphetamine treatment increased the frequency of rearing in the middle at the choice point of the Y-maze. Haloperidol pre-treatment blocked this increase at the midpoint on day 1, and blocked the rearing behavior at the end of an arm on day 2.
4/ Amphetamine also increased the frequency of head turning and "looking", - an effect that was also prevented by haloperidol. (day 2 onwards).
5/ Haloperidol increased the duration of" looking" and of rearing at the end of an arm later in testing..
Conclusions:
Two effects are postulated to have occurred.
a) a conflict on day 1 between the novelty-controlled sensory or attentional effects, that leads to an alternation of arm-choice, and amphetamine-induced DA activity that facilitates an alternation of behavioural responses: -- the result was random choice and increased rearing at the choice point.
b) On days 2-4 the drug-induced effects on switching motor responses came to control behaviour
altloc:
- http://www.biopsychology.uni-essen.de/Rat-Amph-Alternation-1985.htm
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creators_name:
- family: Oades
given: R.D.
honourific: ''
lineage: ''
- family: Taghzouti
given: K.
honourific: ''
lineage: ''
- family: Simon
given: H.
honourific: ''
lineage: ''
- family: Le Moal
given: M.
honourific: ''
lineage: ''
date: 1985
date_type: published
datestamp: 2001-04-05
department: ~
dir: disk0/00/00/14/35
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eprintid: 1435
fileinfo: /style/images/fileicons/application_pdf.png;/1435/2/rat%2Damph%2D85.pdf
full_text_status: public
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keywords: 'dopamine, DA, amphetamine, haloperidol, Y-maze, alternation, rearing, collateral behaviour, switching, novelty, attention, grooming, locomotion, rat, observing-response'
lastmod: 2011-03-11 08:54:37
latitude: ~
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metadata_visibility: show
note: ~
number: ~
pagerange: 123-128
pubdom: TRUE
publication: Psychopharmacology
publisher: Springer-Verlag
refereed: TRUE
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relation_type: []
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reportno: ~
rev_number: 10
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status_changed: 2007-09-12 16:37:46
subjects:
- behav-neuro-sci
- bio-behav
- neuro-pharm
- physio-psy
- psy-bio
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: 'Dopamine-sensitive alternation and collateral behaviour in a Y-maze: effects of d-amphetamine and haloperidol'
type: journalp
userid: 1054
volume: 85