?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Attention+deficit+disorder+with+hyperactivity+(ADDH)%3A+the+contribution+of+catecholaminergic+activity&rft.creator=Oades%2C+R.+D.&rft.subject=Neuropharmacology&rft.subject=Neuropsychiatry&rft.subject=Physiological+Psychology&rft.subject=Psychobiology&rft.description=Introduction%3A+%0AAn+attention+deficit+disorder+with+hyperactivity+in+children+(ADDH%2C+later+known+as+ADHD)+is+now+recognized+in+most+countries%2C+although+diagnostic+practices+differ.+Evidence+is+presented+to+show+that+the+two+cardinal+symptoms+of+poor+attentional+performance+and+a+high+degree+of+motor+activity+may+be+functionally+and+causally+separate.%0A%0APsychobiology%3A+%0ABoth+attentional+and+motor-activity+alterations+are+temporarily+relieved+in+a+proportion+of+subjects+that+respond+to+psychostimulants.+Beneficial+treatment+decreases+noradrenergic+(NA)+metabolism+and+normalizes+variable+levels+of+dopaminergic+(DA)+metabolism.+%0A%0AClinical+and+animal+models%3A%0AParallels+are+drawn+with+other+clinical+syndromes+arising+from+changed+catecholaminergic+activity+(cf.+Phenylketonuria%2C+Tourette's+syndrome%2C+Lesch-Nyhan+syndrome)+and+with+behavioral+interpretations+of+the+result+of+damage+to+the+dorsal+noradrenergic+bundle+and+dopaminergic+VTA+A10+nucleus+(an+animal+model).+%0A%0ABiopsychological+research+directions%3A%0APrognosis+of+ADDH+subjects+after+treatment+remains+relatively+poor.+There+may+be+a+further+defect+of+neurotransmitter+metabolism+in+the+ADDH+syndrome.+Research+strategies+are+suggested+based+on+the+neurobiological+correlates+of+the+cognitive+style+of+ADDH+subjects+and+limbic%2Fseptal+function+in+the+animal+model+of+the+spontaneously+hypertensive+rat+(SHR)%0A%0ATopics%3A%0A1+.+Psychostimulant+response+...+Catecholamines+%2F+Serotonin%2C%0A2+.+Electrophysiological+and+behavioral+indices+%0A3+.+Responses+to+monoaminergic+agents+...+Precursors%2C+L-DOPA%2C+amino+acids%2C+monoamine+oxidase+and+others%3A%0A4+.+Clinical+comparisons+...+Phenylketonuria%2C+Tourette's+syndrome%2C+Lesch-Nyhan+syndrome%3A%0A5+.+Models+...+spontaneously+hypertensive+rat%2C+neurobiology+of+hypertension+Noradrenaline+(NA)%2C+Glutamate+(Glu)%2C+Neuropeptide+Y+(NPY)+%26+Angiotensin%2C+Serotonin+(5-HT)%2C+Dopamine+(DA)%3A%0A6+.+Link+between+behavior+and+cognition+...+the+septum+and+conditioned+blocking+measures+of+selective+attention.%0A&rft.publisher=Pergamon&rft.date=1987&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1461%2F2%2Fadhd-CA-rev-87.pdf&rft.identifier=++Oades%2C+R.+D.++(1987)+Attention+deficit+disorder+with+hyperactivity+(ADDH)%3A+the+contribution+of+catecholaminergic+activity.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1461%2F