---
abstract: |-
  Introduction: 
  In view of reports that fimbria-fornix or hippocampal lesions impair working rather than reference memory in a radial maze (Olton et al., 1979) the performance of rodents with hippocampal damage was examined on a hole-board search task.
  
  Methods:
  Food-deprived animals searched for food pellets placed consistently in 4 holes of a 16-hole-board (figure 1). They were presented with 11 sessions of 10 trials/session. There were three groups of animals, - one with aspiration lesions of the hippocampus and overlying neocortex, one with damage only to the overlying neocortex and sham-controls that went through the procedure but the brain was left intact (Oades and Isaacson, 1978). Half of each group received haloperidol (0.275 mg/kg) or saline injections 15 minutes before each of the sessions 4-10.
  Working memory error = a visit to a correct hole that has just been visited, and thus no longer contains a food pellet.
  Reference memory error = visit to a hole that is never baited.
  
  Results: 
  1/ Hippocampal damage resulted in poorer performance on both working and reference memory measures: this was unaffected by haloperidol treatment.
  2/ Neuroleptic treatment also impaired the performance of the sham-controls on both measures.
  3/ Animals with neocortical damage were impaired on reference mmeory measures alon, after haloperidol treatment.
  
  Conclusions:
  .The lack of a neuroleptic effect on performance after hippocampal damage suggests that this lesion does not impair performance on these two measures of memory performance through a dopaminergic mechanism. 
  Haloperidol impaired working memory measures in sham-controls, but only reference memory measures in the neocortical group.. The results imply that there are (at least) three separate mechanisms (i.e. meso-cortico-limbic interactions) at work here involved in shorter- and longer-term consolidation of the consequences of selective attention mechanism required to efficiently learn a search task.
altloc:
  - http://www.biopsychology.uni-essen.de/Rat-VTA-Biol-Psychol-1981.htm
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creators_name:
  - family: Oades
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date: 1981
date_type: published
datestamp: 2001-05-16
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keywords: 'attention, search, working memory, reference memory, holeborad, hippocampus, neocortex, mesolimbic, mesocortical, dopamine, DA, VTA, haloperidol, psychosis model, '
lastmod: 2011-03-11 08:54:38
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pagerange: 77-85
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publication: Biological Psychology
publisher: North-Holland
refereed: TRUE
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rev_number: 10
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status_changed: 2007-09-12 16:38:19
subjects:
  - behav-neuro-sci
  - neuro-pharm
  - psy-bio
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title: 'Impairments of search behaviour in rats after haloperidol treatment, hippocampal or neocortical damage suggest a mesocorticolimbic role in cognition'
type: journalp
userid: 1054
volume: 12
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