TY - GEN ID - cogprints152 UR - http://cogprints.org/152/ A1 - Zaidel, Dahlia W. Y1 - 1999/01// N2 - Background: Previous findings in adults revealed significant hemispheric asymmetry in size of neuronal somata in hippocampal subfield CA2 (the “resistant sector”) with no age-related changes. Paucity of quantitative data on the developmental status of these “protected” neurons has led to the investigation of their morphology in comparison to neurons in adjacent subfield CA3, bilaterally. Methods: Bilateral coronal sections from postmortem hippocampus, 24 and 76 weeks postmenstrual age (gestational age plus postnatal age) were studied. The neurons were digitized and measured on a computer. Results: Soma size correlated positively and significantly with age in CA2 and CA3, bilaterally. CA2 somata were significantly larger (left 34%, right 32%) than adjacent CA3 somata. Variability in soma form or size increased appreciably with age, in both subfields, bilaterally, while variability in soma orientation was weakly correlated with brain growth. Conclusions: The results suggest that in early development there are similarities in hemispheric growth patterns in CA2 and CA3. Large CA2 soma size implies axonal connectivity to distantly located targets very early in development. The results have functional implications, including memory, to brain development KW - brain KW - migration KW - early KW - infant KW - post mortem KW - histology KW - morphology KW - neuron size KW - neuron shape KW - neuron orientation KW - CA2 KW - CA3 KW - development KW - growth KW - microscope KW - computerized microscopy KW - soma size KW - soma shape KW - soma orientation KW - variability KW - age KW - hemispheric specialization KW - anatomical asymmetry KW - anatomy KW - human KW - neuron KW - morphogenesis KW - memory KW - connectivity KW - axon KW - connections KW - schizophrenia. TI - Quantitative morphology of human hippocampus early neuron development SP - 87 AV - public EP - 91 ER -