?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=p-Chlorophenylalanine-produced+effects+on+behavior+in+intact+and+brain-damaged+rats&rft.creator=Oades%2C+R.D.&rft.creator=Isaacson%2C+&rft.subject=Behavioral+Neuroscience&rft.subject=Neuropharmacology&rft.subject=Psychobiology&rft.description=Introduction%3A+%0AOur+aim+was+to+determine+if+a+reduction+of+serotonin+(5-HT)+synthesis+in+the+brain+would+provide+any+protection+from+the+behavioral+alterations+induced+by+hippocampal+brain-damage.+The+development+of+open-field+activity+(5+minute+sessions)+over+two+weeks+and+the+acquisition+of+a+passive+avoidance+task+were+chosen+for+study.%0A%0AMethods%3A%0AThere+were+3+groups+of+lesioned+rats+-+those+hippocampal+aspiration+lesions%2C+those+with+only+damage+to+the+neocortex+overlying+the+hippocampus%2C+and+a+sham-operated+group.+Half+of+each+group+was+treated+300+mg%2Fkg+p-chlorphenylalanine+(PCPA)+for+3+successive+days+to+deplete+levels+of+5-HT+and+the+other+half+were+given+the+saline+vehicle+alone.%0A%5BHippocampal+damage+is+associated+with+increased+activity+in+the+open+field+and+impaired+learning+of+the+step-through+passive+avoidance+response.%5D%0A%0AResults%3A+%0A1%2F+Animals+with+hippocampal+damage+became+hyperactive+in+the+second+week+after+operation.%0A2%2F+PCPA+treatment+had+no+effect+on+locomotion%2C+(nor+on+the+frequently+observed+thigmotaxic+nature+of+the+behavior)+%0A3%2F+Rearing+was+initially+depressed+after+the+operation%2C+and+PCPA+treatment+facilitated+its+recovery+-+but+PCPA+decreased+rearing+in+intact+animals+during+the+second+week+of+testing.%0A4%2F+Reduced+levels+of+grooming+were+seen+in+hippocampal+animals%2C+while+PCPA+reduced+grooming+in+those+with+neocortical+damage%0A5%2F+The+animals+with+hippocampal+damage+were+impaired+in+witholding+response+in+the+passive+avoidance+task+-+those+treated+with+PCPA+performed+even+worse+in+not+witholding+the+shock-reinforced+step-through+response.+This+contrasted+with+the+intact+animals%2C+where+PCPA+treatment+reduced+the+amount+of+footshock+the+animals+were+exposed+to+in+the+task%0A%0AConclusions%3A%0A.The+results+are+consistent+with+a+role+for+mesolimbic+5-HT+innervation+of+the+dorsal+hippocampus+having+an+influence+on+novelty-elicited+responses+(e.g.+grooming+in+home+vs.+novel+cage+and+investigative+rearing+behavior)+and+in+modulation+of+the+sensitivity+of+response+to+electric+footshock+(hypersensitive+in+PCPA-intact+animals%2C+hyposensitive+in+PCPA-hippocampal+animals).%0A&rft.publisher=Academic+Press&rft.date=1977&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1520%2F2%2Frat-pcpa-77.pdf&rft.identifier=++Oades%2C+R.D.+and+Isaacson%2C+++(1977)+p-Chlorophenylalanine-produced+effects+on+behavior+in+intact+and+brain-damaged+rats.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1520%2F