?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Direct+Current+Auditory+Evoked+Potentials+During+Wakefulness%2C+Anesthesia%2C+and+Emergence+from+Anesthesia&rft.creator=Fitzgerald%2C+Robert&rft.creator=Lamm%2C+Claus&rft.creator=Oczenski%2C+Wolfgang&rft.creator=Stimpfl%2C+Thomas&rft.creator=Vycudilik%2C+Walter&rft.creator=Bauer%2C+Herbert&rft.subject=Brain+Imaging&rft.subject=Clinical+Psychology&rft.subject=Neuropharmacology&rft.subject=Neurophysiology&rft.subject=Physiological+Psychology&rft.description=Direct+current+auditory+evoked+potentials+(DC-AEPs)%0Aare+a+sensitive+indicator+of+depth+of+anesthesia+in+ani-mals.+However%2C+they+have+never+been+investigated+in%0Ahumans.+To+assess+the+potential+usefulness+of+DC-AEPs%0Aas+an+indicator+of+anesthesia+in+humans%2C+we+performed%0Aan+explorative+study+in+which+DC-AEPs+were+recorded%0Aduring+propofol+and+methohexital+anesthesia+in+hu-mans.%0ADC-AEPs+were+recorded+via+22+scalp+electrodes%0Ain+19+volunteers+randomly+assigned+to+receive+either%0Apropofol+or+methohexital.+DC-AEPs+were+evoked+by%0Abinaurally+presented+2-s%2C+60-dB%2C+800-Hz+tones%3B+meas-urements%0Awere+taken+during+awake+baseline%2C+anesthesia%2C%0Aand+emergence.+Statistical+analysis+included+analy-sis%0Aof+variance+and+discriminant+analysis+of+data%0Aacquired+during+these+three+conditions.+About+500+ms%0Aafter+stimulus+presentation%2C+DC-AEPs+could+be+ob-served.%0AThese+potentials+were+present+only+during+base-line%0Aand+emergence%C2%97not+during+anesthesia.+Statistically%0Asignificant+differences+were+found+between%0Abaseline+and+anesthesia+and+between+anesthesia+and%0Aemergence.+In+conclusion%2C+similar+effects%2C+as+reported+in%0Aanimal+studies+of+anesthetics+on+the+DC-AEPs%2C+could+be%0Aobserved+in+anesthetized+humans.+These+results+dem-onstrate%0Athat+DC-AEPs+are+potentially+useful+in+the+assessment%0Aof+cortical+function+during+anesthesia+and%0Amight+qualify+the+method+for+monitoring+anesthesia+in%0Ahumans.&rft.date=2001&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1633%2F3%2Fanesthesia_analgesia2001.pdf&rft.identifier=++Fitzgerald%2C+Robert+and+Lamm%2C+Claus+and+Oczenski%2C+Wolfgang+and+Stimpfl%2C+Thomas+and+Vycudilik%2C+Walter+and+Bauer%2C+Herbert++(2001)+Direct+Current+Auditory+Evoked+Potentials+During+Wakefulness%2C+Anesthesia%2C+and+Emergence+from+Anesthesia.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1633%2F