---
abstract: |-
Direct current auditory evoked potentials (DC-AEPs)
are a sensitive indicator of depth of anesthesia in ani-mals. However, they have never been investigated in
humans. To assess the potential usefulness of DC-AEPs
as an indicator of anesthesia in humans, we performed
an explorative study in which DC-AEPs were recorded
during propofol and methohexital anesthesia in hu-mans.
DC-AEPs were recorded via 22 scalp electrodes
in 19 volunteers randomly assigned to receive either
propofol or methohexital. DC-AEPs were evoked by
binaurally presented 2-s, 60-dB, 800-Hz tones; meas-urements
were taken during awake baseline, anesthesia,
and emergence. Statistical analysis included analy-sis
of variance and discriminant analysis of data
acquired during these three conditions. About 500 ms
after stimulus presentation, DC-AEPs could be ob-served.
These potentials were present only during base-line
and emergence—not during anesthesia. Statistically
significant differences were found between
baseline and anesthesia and between anesthesia and
emergence. In conclusion, similar effects, as reported in
animal studies of anesthetics on the DC-AEPs, could be
observed in anesthetized humans. These results dem-onstrate
that DC-AEPs are potentially useful in the assessment
of cortical function during anesthesia and
might qualify the method for monitoring anesthesia in
humans.
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creators_id: []
creators_name:
- family: Fitzgerald
given: Robert
honourific: ''
lineage: ''
- family: Lamm
given: Claus
honourific: ''
lineage: ''
- family: Oczenski
given: Wolfgang
honourific: ''
lineage: ''
- family: Stimpfl
given: Thomas
honourific: ''
lineage: ''
- family: Vycudilik
given: Walter
honourific: ''
lineage: ''
- family: Bauer
given: Herbert
honourific: ''
lineage: ''
date: 2001
date_type: published
datestamp: 2001-06-20
department: ~
dir: disk0/00/00/16/33
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eprint_status: archive
eprintid: 1633
fileinfo: /style/images/fileicons/application_pdf.png;/1633/3/anesthesia_analgesia2001.pdf
full_text_status: public
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ispublished: pub
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keywords: 'anesthesia, DC-potentials, monitoring of anesthesia, EEG, consciousness'
lastmod: 2011-03-11 08:54:43
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metadata_visibility: show
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pagerange: 154-160
pubdom: FALSE
publication: Anesthesia and Analgesia
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refereed: TRUE
referencetext: |-
1. Thornton C, Sharpe RM. Evoked responses in anaesthesia. Br J Anaesth 1998; 81:771-781
2. David E, Finkenzeller P, Kallert S, Keidel WD. Reizkorrelierte Gleichspannungs-änderungen der primären Hörrinde an der wachen Katze. Pflügers Archiv 1969; 306: 281-89
3. Keidel WD. D.C.-potentials in the auditory response in man. Acta Otolaryng 1971; 71: 242-48
4. Annett M. Left, right, hand and brain: the right shift theory. London: Erlbaum, 1985
5. Bauer H, Korunka C, Leodolter M. Technical requirements for high-quality scalp DC recordings. Electroencephalogr clin Neurophysiol 1989; 72: 545-47
6. Bauer H. Slow potential topography. Behavior Res Meth Instr Comp 1998; 30: 20-33
7. Bauer H, Steinringer H, Schock P. A new highly sensitive DC-amplifier for steady bio-potential recording. Archiv für Psychologie 1980; 133: 333-37
8. Vitouch O, Bauer H, Gittler G, et al. Cortical activity of good and poor spatial test per-formers during spatial and verbal processing studied with Slow Potential Topography. Intern J Psychophysiol 1997; 27: 183-99
9. Vasey MW, Thayer JF. The continuing problem of false positives in repeated measures ANOVA in psychophysiology: a multivariate solution. Psychophysiology 1987; 24: 479-86
10. Greenhouse SW, Geisser S. On methods in the analysis of profile data. Psychometrika 1959; 24: 95-112.
11. Boik RJ. A priori tests in repeated measures designs: effects of nonsphericity. Psy-chometrika 1981; 46: 241-55
12. Köhler W, Neff WD, Wegener J. Currents of the human auditory cortex in the cat. J Cell Comp Physiol 1955; 45 (Suppl 1): 1-24
13. Picton TW, Woods DL, Proulx GB. Human auditory sustained potentials. I. The nature of the response. Electroencephalogr Clin Neurophysiol 1978; 45: 186-97
14. Davis H. Principles of electric response audiometry. Ann Otol Rhinol Laryngol 1976; 85 (Suppl. 28): 5-96
15. Starr A, Don M. Brain potentials evoked by acoustic stimuli. In: Picton TW, ed. Hand-book of electroencephalography and clinical neurophysiology. Revised Series Vol. 3. Am-sterdam: Elsevier, 1988: 97-158
16. Sebel PS, Ingram DA, Flynn PJ, et al. Evoked potentials during isoflurane anaesthesia. Br J Anaesth 1986; 58: 580-5
17. Drummond JC, Todd MM, Schubert A, Sang H. Effect of the acute administration of high dose pentobarbital on human brain stem auditory and median nerve somatosensory evoked responses. Neurosurgery 1987; 20: 830-5
18. Schneider G, Sebel PS. Monitoring depth of anesthesia. Eur J Anesthesiol 1997 Suppl; 15:21-8
19. de Beer NA, van Hooff JC, Brunia CH, et al. Midlatency auditory evoked potentials as indicators of perceptual processing during general anesthesia. Br J Anaesth 1996; 77: 617-24
20. Schwender D, Daunderer M, Schnatmann N, et al. Midlatency auditory evoked poten-tials and motor signs of wakefulness during anaesthesia with midazolam. Br J Anaesth 1997; 79: 53-8
21. Davies FW, Mantzaridis H, Kenny GN, Fisher AC. Middle latency auditory evoked potentials during repeated transitions from consciousness to unconsciousness. Anaesthesia 1996; 51: 107-13
22. Plourde G, Boylan JF. The long-latency auditory evoked potential as a measure of the level of consciousness during sufentanil anesthesia. J Cardiothorac Vasc Anesth 1991; 5: 577-83
23. Plourde G, Picton TW. Long-latency auditory evoked potentials during general anes-thesia: N1 and P3 components. Anesth Analg 1991; 72: 342-50
24. Plourde G, Stapells DR, Picton TW. The human auditory steady-state evoked poten-tials. Acta Otolaryngol 1991; 491 Suppl: 153-9
25. Plourde G, Villemure C, Fiset P, et al. Effect of isoflurane on the auditory steady-state response and on consciousness in human volunteers. Anesthesiology 1998; 89: 844-51
26. Birbaumer N, Elbert T, Canavan AGM, Rockstroh B. Slow potentials of the cerebral cortex and behavior. Physiol Rev 1990; 70: 1-41
27. Heinemann U, Walz W. Contribution of potassium currents and glia to slow potential shifts (SPSs). In: Laming PR, Sykova E, Reichenbach A, Hatton GI, Bauer H, eds. Glial cells: their role in behaviour. Cambridge: Cambridge University Press, 1998: 197-209
28. Roitbak AI, Fanardijan VV, Melkonyan DS, Melkonyan AA. Contribution of glia and neurons to the surface-negative potentials of the cerebral cortex during its electrical stimulation. Neuroscience 1987; 20: 1057-1067
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status_changed: 2007-09-12 16:39:13
subjects:
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title: 'Direct Current Auditory Evoked Potentials During Wakefulness, Anesthesia, and Emergence from Anesthesia'
type: journalp
userid: 223
volume: 92