?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=The+effect+of+unilateral+6-hydroxydopamine+lesions+in+the+substantia+nigra+on+hippocampal+noradrenaline-induced+feeding+and+other+behaviour+in+the+rat&rft.creator=Oades%2C+&rft.subject=Behavioral+Neuroscience&rft.subject=Neuropharmacology&rft.subject=Psychobiology&rft.description=Introduction%3A+%0AGiven+that+administration+of+noradrenaline+(NA)+to+the+cerebral+ventricles+or+into+the+hippocampus+can+elicit+feeding%2C+and+that+lesion+the+the+dopaminergic+(DA)+substantia+nigra+(SN)+can+bring+about+aphagia%2C+the+present+report+considers+the+interaction+of+these+two+manipulations.%0A%0AMethods%3A%0ACannulae+were+implanted+into+the+SN+and+the+dorsal+hippocampus+of+rats+kept+on+a+normal+food+and+water+regimen.%0AOne+week+after+surgery+13+%C2%B5g+NA+in+0.6+%C2%B5l+were+administered+to+the+hippocampus+and+the+animals+were+observed+for+20+minutes+or+until+3+minutes+had+elapsed+after+feeding+had+stopped.%0AThe+behavioural+effects+of+6-hydroxydopamine+lesions+of+the+SN+were+recorded+from+a+circular+open+arena.%0A%0AResults%3A+%0A1%2F+Feeding+in+short+bouts+was+elicited+after+NA+injection+to+25%2F30+sites+in+the+hippocampus%0A2%2F+More+feeding+was+observed+from+sites+where+later+histology+suggested+there+had+been+no+leakage+to+the+ventricles+(88%25).+The+feeding+behavior+did+not+result+from+spreading+depression+(%3E7+shakes+recorded+on+3%25+of+tests).%0A3%2F+After+SN+lesion%2C+NA+still+elicited+feeding+from+all+hippocampal+sites+(on+two+or+more+occasions).%0A4%2F+The+SN+lesion+did+not+alter+the+latency+to+feed%2C+the+duration+of+feeding+or+the+intake+of+food.+(A+temporary+decrease+of+body+weight+was+registered+on+the+third+postoperative+day%2C+only).%0A5%2F+NA+treatment+did+not+affect+locomotion+(pre-+or+post-lesion)+although+the+lesion+on+its+own+increased+the+latency+to+move+and+rotation+in+the+open+field.%0A%0AConclusions%3A%0AUnilateral+SN-6-OHDA+treatment+did+not+affect+feeding+elicited+by+ipsi-+or+contralateral+hippocampal+teatment+with+NA.%0AIt+is+suggested+that+6-OHDA+induced+hypophagia+may+result+from+non-specific+effects+of+treatment+as+the+latencies+to+rest%2C+the+duration+of+grooming+increased+and+feeding+bout-duration+decreased+following+the+injection+of+vehicle+or+toxin.%0A&rft.publisher=Elsevier&rft.date=1977&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1637%2F2%2FRat-spread-depres-Nsci-Lett-78.pdf&rft.identifier=++Oades%2C+++(1977)+The+effect+of+unilateral+6-hydroxydopamine+lesions+in+the+substantia+nigra+on+hippocampal+noradrenaline-induced+feeding+and+other+behaviour+in+the+rat.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1637%2F