?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Neuropsychological+and+conditioned+blocking+performance+in+patients+with+schizophrenia%3A+assessment+of+the+contribution+of+neuroleptic+dose%2C+serum+levels+and+dopamine+D2-receptor+occupancy&rft.creator=Oades%2C+R.D.&rft.creator=Rao%2C+M.L.&rft.creator=Bender%2C+S.&rft.creator=Sartory%2C+G.&rft.creator=M%C3%BCller%2C+B.W.&rft.subject=Neurochemistry&rft.subject=Neuropharmacology&rft.subject=Neuropsychology&rft.subject=Neuropsychiatry&rft.subject=Psychobiology&rft.description=Introduction%3A+%0APatients+with+schizophrenia+are+widely+reported+to+show+impairments+of+attention+and+neuropsychological+performance%2C+but+the+extent+to+which+this+is+attributable+to+medication+and+dopamine+(DA)+function+remains+largely+unexplored.+%0A%0AMethods%3A+%0AWe+describe+here+the+putative+influence+of+1)+the+dose+of+antipsychotic+medication+(chlorpromazine+equivalents%2C+CPZ)%2C+2)+the+antipsychotic+serum+concentration+(neuroleptic+units+in+terms+of+butyrophenone+displacement+from+animal+neostriatum)+and+3)+the+approximated+DA+D2-receptor+occupancy+in+the+brain+(based+on+regression+curves+from+11+studies+published+for+5+neuroleptics)+-+-+on+conditioned+blocking+(CB)+measures+of+attention+and+performance+on+a+neuropsycholog-ical+battery.+We+studied+108+patients+with+schizophrenia+with+62+healthy+controls.+%0A%0AResults%3A+%0A1)+Antipsychotic+serum+concentration+and+D2-occupancy+were+higher+in+patients+with+a+paranoid+vs.+non-paranoid+diagnosis%2C+and+in+female+vs.+male+patients+(independent+of+symptom+severity).+%0A2)+Controlling+for+D2-occupancy+removed+the+difference+between+high+CB+in+paranoid+and+impaired+low+CB+measures+of+selective+attention+in+nonparanoid+patients.%0A3)+Similar+partial+correlations+for+antipsychotic+drug+dose+and+serum+levels+of+DA+D2-blocking+activity+with+performance+on+the+trail-making+and+picture+completion+tests+(negative)+and+the+block-design+test+(positive)+showed+the+functional+importance+of+DA-related+activity.+%0A4)+High+estimates+of+D2-occupancy+were+related+to+impaired+verbal+fluency+-+but+-+were+associated+with+improved+recall+of+stories%2C+especially+in+paranoid+patients.+%0A5)+Non-dopaminergic+aspects+of+medication+(i.e.+CPZ-dependent+but+not+D2-occupancy-associated)+impaired+verbal+recall+in+males+(left-hemisphere+function)+and+non-verbal+performance+in+females+(reflecting+right+hemisphere+function).%0A%0AConclusions%3A+%0AThis+first+study+of+its+kind+tentatively+imputes+a+role+for+DA+D2-related+activity+in+left+frontal+(e.g.+CB+and+verbal+fluency)+and+temporal+lobe+functions+(verbal+recall)%2C+as+well+as+in+some+non-verbal+abilities+mediated+more+in+the+right+hemisphere+of+patients+with+schizophrenia%0A%0A&rft.publisher=Lippincott+Williams+Wilkins&rft.date=2000&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F1843%2F2%2Fschiz-Behav-Pharmacol-2000-art.pdf&rft.identifier=++Oades%2C+R.D.+and+Rao%2C+M.L.+and+Bender%2C+S.+and+Sartory%2C+G.+and+M%C3%BCller%2C+B.W.++(2000)+Neuropsychological+and+conditioned+blocking+performance+in+patients+with+schizophrenia%3A+assessment+of+the+contribution+of+neuroleptic+dose%2C+serum+levels+and+dopamine+D2-receptor+occupancy.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F1843%2F