?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Dehydroepiandrosterone+sulphate+and+corticotropin+levels+are+high+in+young+male+patients+with+conduct+disorder%3A+comparisons+with+growth+factors%2C+thyroid+and+gonadal+hormones&rft.creator=Dmitrieva%2C+&rft.creator=Oades%2C+&rft.creator=Hauffa%2C+&rft.creator=Eggers%2C+&rft.subject=Developmental+Psychology&rft.subject=Neuroendocrinology&rft.subject=Neuropsychiatry&rft.subject=Psychobiology&rft.description=Introduction%3A+The+biological+concomitants+of+childhood+conduct+disorder+(CD)+have+seldom+been+considered+separate+from+those+of+hyperkinesis+with+which+CD+is+often+comorbid.+CD+predicts+an+increased+likelihood+of+developing+a+personality+disorder+and+is+often+associated+with+an+antisocial+outcome.+Childhood+CD+may+originate+in+a+stressful+upbringing+in+a+dysfunctional+family+environment%2C+and+has+been+reported+to+be+associated+with+unusual+physical+or+sexual+development+and+thyroid+dysfunction.+%0A%0AMethods%3A+We+therefore+explored+circulating+levels+of+hormones+from+adrenal%2C+gonadal+and+growth-hormone+axes+associated+with+stress%2C+aggression+and+development+in+28+CD+patients+and+13+age-matched+healthy+children+(10-18+years+old).+%0A%0AResults%3A+%0A1%2F+The+CD+group+had+higher+levels+of+dehydroepiandrosterone+sulphate+(DHEA-S)+and+corticotropin+(ACTH)+and+for+those+under+14+years+of+age+there+was+more+free+triiodothyronine+(fT3)+in+the+circulation.+%0A2%2F+There+were+no+differences+for+gonadal+hormones%2C+and+neither+the+levels+of+steroid+hormones+nor+the+ratings+of+maturity+(early%2Flate)+were+associated+with+aggression%2C+as+has+been+reported+elsewhere.+3%2F+Smaller+physical+measures+in+CD+children+correlated+with+DHEA-S+and+growth+factors+(e.g.+IGF-I)%3A+4%2F+increased+ACTH+and+fT3+correlated+with+restless-impulsive+ratings%2C+and+DHEA-S+with+'disruptive+behaviour'.+%0A%0AConclusions%3A+Imbalances+in+the+adrenal+and+growth+axes+may+indeed+have+neurotrophic+repercussions+in+growth+and+development.%0A%0A&rft.publisher=Karger&rft.date=2001&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F2018%2F2%2FCD-Neuropsychobiol-2001-art.pdf&rft.identifier=++Dmitrieva%2C++and+Oades%2C++and+Hauffa%2C++and+Eggers%2C+++(2001)+Dehydroepiandrosterone+sulphate+and+corticotropin+levels+are+high+in+young+male+patients+with+conduct+disorder%3A+comparisons+with+growth+factors%2C+thyroid+and+gonadal+hormones.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F2018%2F<script src='//archive-bar.soton.ac.uk/archive-bar.js'></script>