This site has been permanently archived. This is a static copy provided by the University of Southampton.
TY - GEN ID - cogprints2018 UR - http://cogprints.org/2018/ A1 - Dmitrieva, A1 - Oades, A1 - Hauffa, A1 - Eggers, Y1 - 2001/// N2 - Introduction: The biological concomitants of childhood conduct disorder (CD) have seldom been considered separate from those of hyperkinesis with which CD is often comorbid. CD predicts an increased likelihood of developing a personality disorder and is often associated with an antisocial outcome. Childhood CD may originate in a stressful upbringing in a dysfunctional family environment, and has been reported to be associated with unusual physical or sexual development and thyroid dysfunction. Methods: We therefore explored circulating levels of hormones from adrenal, gonadal and growth-hormone axes associated with stress, aggression and development in 28 CD patients and 13 age-matched healthy children (10-18 years old). Results: 1/ The CD group had higher levels of dehydroepiandrosterone sulphate (DHEA-S) and corticotropin (ACTH) and for those under 14 years of age there was more free triiodothyronine (fT3) in the circulation. 2/ There were no differences for gonadal hormones, and neither the levels of steroid hormones nor the ratings of maturity (early/late) were associated with aggression, as has been reported elsewhere. 3/ Smaller physical measures in CD children correlated with DHEA-S and growth factors (e.g. IGF-I): 4/ increased ACTH and fT3 correlated with restless-impulsive ratings, and DHEA-S with 'disruptive behaviour'. Conclusions: Imbalances in the adrenal and growth axes may indeed have neurotrophic repercussions in growth and development. PB - Karger KW - Child KW - Adolescent KW - Conduct Disorder KW - Hormones KW - Steroids KW - Peptides KW - Dehydroepiandrosterone KW - DHEA KW - DHEAS KW - corticotropin KW - ACTH KW - Growthm Maturation KW - Puberty KW - Androgen KW - Testosterone KW - Oestrogen KW - Luteinizing hormone KW - Follicular stimulating hormone KW - prolactin KW - Thyroid KW - Thyroid stimulating hormone KW - TSHtri-iodothyronine KW - fT3 KW - fT4 KW - IGF-1 KW - IGFBP-3 KW - Insulin-like growth factor KW - hyperactivity KW - impulsivity KW - aggression KW - TI - Dehydroepiandrosterone sulphate and corticotropin levels are high in young male patients with conduct disorder: comparisons with growth factors, thyroid and gonadal hormones SP - 134 AV - public EP - 140 ER -