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abstract: |+
Introduction: The biological concomitants of childhood conduct disorder (CD) have seldom been considered separate from those of hyperkinesis with which CD is often comorbid. CD predicts an increased likelihood of developing a personality disorder and is often associated with an antisocial outcome. Childhood CD may originate in a stressful upbringing in a dysfunctional family environment, and has been reported to be associated with unusual physical or sexual development and thyroid dysfunction.
Methods: We therefore explored circulating levels of hormones from adrenal, gonadal and growth-hormone axes associated with stress, aggression and development in 28 CD patients and 13 age-matched healthy children (10-18 years old).
Results:
1/ The CD group had higher levels of dehydroepiandrosterone sulphate (DHEA-S) and corticotropin (ACTH) and for those under 14 years of age there was more free triiodothyronine (fT3) in the circulation.
2/ There were no differences for gonadal hormones, and neither the levels of steroid hormones nor the ratings of maturity (early/late) were associated with aggression, as has been reported elsewhere. 3/ Smaller physical measures in CD children correlated with DHEA-S and growth factors (e.g. IGF-I): 4/ increased ACTH and fT3 correlated with restless-impulsive ratings, and DHEA-S with 'disruptive behaviour'.
Conclusions: Imbalances in the adrenal and growth axes may indeed have neurotrophic repercussions in growth and development.
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- http://www.biopsychology.uni-essen.de/neuropsychobiol.htm
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- family: Dmitrieva
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- family: Oades
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- family: Hauffa
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- family: Eggers
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date: 2001
date_type: published
datestamp: 2002-01-11
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keywords: 'Child, Adolescent, Conduct Disorder, Hormones, Steroids, Peptides, Dehydroepiandrosterone, DHEA, DHEAS, corticotropin, ACTH, Growthm Maturation, Puberty, Androgen, Testosterone, Oestrogen, Luteinizing hormone, Follicular stimulating hormone, prolactin, Thyroid, Thyroid stimulating hormone, TSHtri-iodothyronine, fT3, fT4, IGF-1, IGFBP-3, Insulin-like growth factor, hyperactivity, impulsivity, aggression, '
lastmod: 2011-03-11 08:54:52
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pagerange: 134-140
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publication: Neuropsychobiology
publisher: Karger
refereed: TRUE
referencetext: |
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relation_type: []
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reportno: ~
rev_number: 10
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status_changed: 2007-09-12 16:42:25
subjects:
- dev-psy
- neuro-endocrin
- neuro-psych
- psy-bio
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: 'Dehydroepiandrosterone sulphate and corticotropin levels are high in young male patients with conduct disorder: comparisons with growth factors, thyroid and gonadal hormones'
type: journalp
userid: 1054
volume: 43