?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Culture+and+Cancer&rft.creator=Wallace%2C+Dr.+Rodrick&rft.creator=Wallace%2C+Dr.+Deborah&rft.creator=Wallace%2C+Dr.+Robert&rft.subject=Theoretical+Biology&rft.description=Genetic+mechanisms%2C+since+they+broadly+involve+information+%0Atransmission%2C+should+be+translatable+into+information+dynamics+formalism.++From+this+perspective+we+reconsider+the+adaptive+mutator%2C+one+possible+means+of+'second+order+selection'+by+which+a+highly+structured+'language'+of+environment+and+development+writes+itself+onto+the+variation+upon+which+evolutionary+selection+and+tumorigenesis+operate.+Our+approach+uses+recent+results+in+the+spirit+of+the+Large+Deviations+Program+of+applied+probability+that+permit+transfer+of+phase+transition+approaches+from+statistical+mechanics+to+information+theory%2C+generating+evolutionary+and+developmental+punctuation+in+what+we+claim+to+be+a+highly+natural+manner.%0A%0A&rft.date=2002-08&rft.type=Preprint&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F2407%2F1%2Fmutator2.pdf&rft.identifier=++Wallace%2C+Dr.+Rodrick+and+Wallace%2C+Dr.+Deborah+and+Wallace%2C+Dr.+Robert++(2002)+Culture+and+Cancer.++%5BPreprint%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F2407%2F