---
abstract: |+
  Genetic mechanisms, since they broadly involve information 
  transmission, should be translatable into information dynamics formalism.  From this perspective we reconsider the adaptive mutator, one possible means of 'second order selection' by which a highly structured 'language' of environment and development writes itself onto the variation upon which evolutionary selection and tumorigenesis operate. Our approach uses recent results in the spirit of the Large Deviations Program of applied probability that permit transfer of phase transition approaches from statistical mechanics to information theory, generating evolutionary and developmental punctuation in what we claim to be a highly natural manner.

altloc: []
chapter: ~
commentary: ~
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contact_email: ~
creators_id:
  - New York State Psychiatric Institute
  - 'Mailman School of Public Health, Columbia University'
  - City University of New York
creators_name:
  - family: Wallace
    given: Rodrick
    honourific: Dr.
    lineage: ''
  - family: Wallace
    given: Deborah
    honourific: Dr.
    lineage: ''
  - family: Wallace
    given: Robert
    honourific: Dr.
    lineage: ''
date: 2002-08
date_type: published
datestamp: 2002-08-15
department: ~
dir: disk0/00/00/24/07
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edit_lock_user: ~
editors_id: []
editors_name: []
eprint_status: archive
eprintid: 2407
fileinfo: /style/images/fileicons/application_pdf.png;/2407/1/mutator2.pdf
full_text_status: public
importid: ~
institution: ~
isbn: ~
ispublished: ~
issn: ~
item_issues_comment: []
item_issues_count: 0
item_issues_description: []
item_issues_id: []
item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'Cancer, cellular cognition, culture, evolution, information theory, interpenetration, mutator, punctuation, renormalization, second order selection, universality'
lastmod: 2011-03-11 08:54:59
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: ~
pagerange: ~
pubdom: FALSE
publication: ~
publisher: ~
refereed: FALSE
referencetext: ~
relation_type: []
relation_uri: []
reportno: ~
rev_number: 12
series: ~
source: ~
status_changed: 2007-09-12 16:44:42
subjects:
  - bio-theory
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: Culture and Cancer
type: preprint
userid: 1845
volume: ~
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