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--- abstract: |+ Genetic mechanisms, since they broadly involve information transmission, should be translatable into information dynamics formalism. From this perspective we reconsider the adaptive mutator, one possible means of 'second order selection' by which a highly structured 'language' of environment and development writes itself onto the variation upon which evolutionary selection and tumorigenesis operate. Our approach uses recent results in the spirit of the Large Deviations Program of applied probability that permit transfer of phase transition approaches from statistical mechanics to information theory, generating evolutionary and developmental punctuation in what we claim to be a highly natural manner. altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - New York State Psychiatric Institute - 'Mailman School of Public Health, Columbia University' - City University of New York creators_name: - family: Wallace given: Rodrick honourific: Dr. lineage: '' - family: Wallace given: Deborah honourific: Dr. lineage: '' - family: Wallace given: Robert honourific: Dr. lineage: '' date: 2002-08 date_type: published datestamp: 2002-08-15 department: ~ dir: disk0/00/00/24/07 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 2407 fileinfo: /style/images/fileicons/application_pdf.png;/2407/1/mutator2.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: ~ issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'Cancer, cellular cognition, culture, evolution, information theory, interpenetration, mutator, punctuation, renormalization, second order selection, universality' lastmod: 2011-03-11 08:54:59 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: ~ pagerange: ~ pubdom: FALSE publication: ~ publisher: ~ refereed: FALSE referencetext: ~ relation_type: [] relation_uri: [] reportno: ~ rev_number: 12 series: ~ source: ~ status_changed: 2007-09-12 16:44:42 subjects: - bio-theory succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Culture and Cancer type: preprint userid: 1845 volume: ~