<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Regulation of Neuromodulator Receptor Efficacy- Implications for Whole-Neuron and Synaptic Plasticity"^^ . "Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release.\nEven though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental factors, its functional consequences and modes of action are not well understood.\nIn this paper we summarize relevant experimental evidence on NM receptor regulation (specifically dopamine D1 and D2 receptors) in order to explore its significance for neural and synaptic plasticity.\nWe identify the relevant components of NM receptor regulation (receptor phosphorylation, receptor\ntrafficking and sensitization of second-messenger pathways)\ngained from studies on cultured cells.\nKey principles in the regulation and control of short-term plasticity (sensitization) are identified, and a model is presented which employs direct and indirect feedback regulation of receptor efficacy. We also discuss long-term plasticity which involves shifts in receptor sensitivity and loss of responsivity to NM signals.\nFinally, we discuss the implications of NM receptor regulation for models\nof brain plasticity and memorization.We emphasize that a realistic model of brain plasticity will have to go\nbeyond Hebbian models of long-term potentiation and depression to include\nplasticity in the distribution and efficacy of NM receptors.\n\n\n"^^ . "2003-02" . . . . . . . "Gabriele"^^ . "Scheler"^^ . "Gabriele Scheler"^^ . . . . . . "Regulation of Neuromodulator Receptor Efficacy- Implications for Whole-Neuron and Synaptic Plasticity (PDF)"^^ . . . . . . "network03.pdf"^^ . . . "Regulation of Neuromodulator Receptor Efficacy- Implications for Whole-Neuron and Synaptic Plasticity (Image (PNG))"^^ . . . . . . "preview.png"^^ . . . "Regulation of Neuromodulator Receptor Efficacy- Implications for Whole-Neuron and Synaptic Plasticity (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #2836 \n\nRegulation of Neuromodulator Receptor Efficacy- Implications for Whole-Neuron and Synaptic Plasticity\n\n" . "text/html" . . . "Computational Neuroscience" . . . "Theoretical Biology" . . . "Neuropharmacology" . .