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<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Frontostriatal deficit in Motor Neuron Disease/Amyotrophic Lateral Sclerosis (MND/ALS)"^^ . "So far, cognitive derangements in MND/ALS have not been widely studied. Nevertheless, it seems that in subgroups of patients cognitive functions are impaired in different degree, so that often at least two sub-types of the syndrome are reported: Motor Neuron Disease/Amyotrophic Lateral Sclerosis/Dementia Syndrome (MND/ALS/DS) and Motor Neuron Disease/Amyotrophic Lateral Sclerosis/ Aphasia Syndrome (MND/ALS/AS. A third subtype showing both symptoms of cognitive impairment may be identified in subgroups of patients and denominated Motor Neuron Disease/Amyotrophic Lateral Sclerosis/Dementia-Aphasia Syndrome (MND/ALS/DAS).\nFrontostriatal system is reported as a network heavily damaged in MND/ALS/DS, MND/ALS/AS, MND/ALS/DAS. The system is plausibly responsible of motor skills and verbs production, hence to become aware of a possible frontostriatal deficit in subgroup of MND/ALS patients might consent us to link at the brain level (motor) action and verbs and possibly ideomotor praxia and verbs. \nWe have used Goal-Oriented Perception Task (GOPT) and Action Fluency Task (AFT) in order to detect with some accuracy impairments related to gestaltic analysis directed toward a goal, and verb retrieval deficits possibly underlying executive system dysfunction that destabilizes the ability to mentally coordinate the information associated with a verb. These tests should consent to detect possible frontostriatal derangements.\nWe have tested 10 MND/ALS patients and 10 healthy subjects matched fore age, sex and laterality. \nAFT showed that 3 out of 6 patients are heavily impaired in this test (6.3 (mean) verbs generated vs 13.3 of the control group). GOPT detected a remarkable impairment in all patients: p=0.0021 (grammatical side), p=0.0002 (perceptual side).\nReported frontostriatal deficit in MND/ALS seems confirmed by this study, and probably it is more easily detected by GOPT than by AFT.\n"^^ . "2003" . . . . . . . . . . . . . . . . . . . . "P"^^ . "Bongioanni"^^ . "P Bongioanni"^^ . . "B"^^ . "Rossi"^^ . "B Rossi"^^ . . "MC"^^ . "Carboncini"^^ . "MC Carboncini"^^ . . "M"^^ . "Magoni"^^ . "M Magoni"^^ . . "G"^^ . "Buoiano"^^ . "G Buoiano"^^ . . . . . . "Frontostriatal deficit in Motor Neuron Disease/Amyotrophic Lateral Sclerosis (MND/ALS) (PDF)"^^ . . . . . . "Frontostriatal_Deficit_in_MND-ALS.pdf"^^ . . . "Frontostriatal deficit in Motor Neuron Disease/Amyotrophic Lateral Sclerosis (MND/ALS) (Image (PNG))"^^ . . . . . . "preview.png"^^ . . . "Frontostriatal deficit in Motor Neuron Disease/Amyotrophic Lateral Sclerosis (MND/ALS) (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #3129 \n\nFrontostriatal deficit in Motor Neuron Disease/Amyotrophic Lateral Sclerosis (MND/ALS)\n\n" . "text/html" . . . "Neuropsychology" . .