This site has been permanently archived. This is a static copy provided by the University of Southampton.
--- abstract: 'In order to determine the most common bacteria implicated in conjunctivitis, and the effectiveness of the antibiotic Fluoroquinolone for its treatment, a total of 50 subjects (100 ) eyes, between the ages of 1-30 years with mean age of 16.94 ± 8.06 years with infected eyes, were examined at the Lagos State University Teaching Hospital, Nigeria (LASUTH). Conjunctival swabs were collected and cultured in the laboratory to isolate the pathogens responsible for the infection. Sensitivity and antibiotic suscepticibility tests were carried out with discs impregnated with 0.3% concentration of ophthalmic topical solutions of chibroxin (Norfloxacin), ciloxan (Ciprofloxacin), and ocuflox (Ofloxacin), to ascertain the most sensitive of the three drugs. The results showed that the implicated bacteria in order of decreasing frequency were Staphylococcus aureus (34%), followed by Streptococcus pneumoniae (22%), Pseudomonas aeruginosa (14%), Klebsiella pneumoniae (12%), Hemophilus influenzae (9%), Escherichia coli (9%). All the isolated organisms were highly sensitive to the three drugs. However, a one way analysis of variance (ANOVA) showed a significant difference in the sensitivity of the three drugs (p< 0.05). ANOVA Post Hoc located Ciprofloxacin as the source of the significance. In conclusion therefore, Ciprofloxacin is the most sensitive of the three drugs and, hence should be the first choice of the fluoroquinolones for the treatment of bacterial conjunctivitis.' altloc: - http://www.ojhas.org/issue7/2003-3-1.htm chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - Idu F - Stella O creators_name: - family: Faustina given: Idu honourific: Dr lineage: '' - family: Odjimogho given: Stella honourific: Ms lineage: '' date: 2003-10 date_type: published datestamp: 2003-10-18 department: ~ dir: disk0/00/00/32/36 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: - Kakkilaya BS editors_name: - family: Kakkilaya given: Srinivas honourific: Dr lineage: Bevinje eprint_status: archive eprintid: 3236 fileinfo: /style/images/fileicons/application_pdf.png;/3236/1/2003%2D3%2D1.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'Conjunctivitis, fluoroquinolones' lastmod: 2011-03-11 08:55:22 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 3 pagerange: ~ pubdom: TRUE publication: Online Journal of Health and Allied Sciences publisher: Kakkilaya BS refereed: TRUE referencetext: |- 1. Vaughan D, Asbury T and Riodan-Eva P. General Ophthalmology, Lange Medical publication, 15th ed. 1996; PP 96-67. 2. Kanski JJ. Clinical Ophthalmology. 3rd ed. Butterworth-Heinemann-Int’l ed. Woburn, MA; 1998.p. 514. 3. Yetman R and Coody D. Conjunctivitis: A practice guideline. J Pediatric HealthCare. 1997;11(5):238-44 4. Wolfson, JS and Hooper DC. The fluoroquinolones: structure, mechanism of action and resistance and spectra of activity in vitro. Antimicrobe Agent chemother. 1985; Pp 28,58. 5. Brower, K., Kowalski, R and Gordon M. Flouroquinolones in the treatment of bacteria keratitis Am J Ophthalmol 1996; 121:712-5. 6. Lu, KL Prajna, NV and Macdonell, PJ. Comparism of Ofloxacin and Ciprofloxacin in the therapy of bacteria keratitis. Invest Ophthalmol Vis Sci 1998; 39:5140. 7. O’brian, TP, Maguire, MG, Fink, NE, Alfonso E and Mcdonnell P. For the bacterial keratitis study group. Efficacy of ofloxacin vs Cefazolin and Tobramycin in the therapy of bacterial keratitis. Arc ophthalmol. 1995; 113:1257-65. 8. Jauch, A. et al Meta analysis of six clinical phase III studies comparing 0.3% lomefloxacin twice daily with five standard antibiotics in patients with acute bacterial conjunctivitis. Graefs Arch Clin Exp Ophthalmol. 1999; In press. 9. Baum, JL. Bacterial conjunctivitis: Diagnosis and Treatment. APUA Newsletter. 1997; 15(4): 1, 4-5, 8. 10. Haesaert, PS. Clinical manual of ocular microbiology and cytology, Mosby year book. 1993; pp 30-32, 68, 102, 114-115. 11. Prescott LM, Harley JP and Klein DA. Microbiology. 4th ed. McGraw-Hills Co, U.S.A; 1999. p. 780. relation_type: [] relation_uri: [] reportno: ~ rev_number: 12 series: ~ source: ~ status_changed: 2007-09-12 16:49:21 subjects: - OJHAS succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: 'Susceptibility of conjunctival bacterial pathogens to fluoroquinolones. A comparative study of ciprofloxacin, norfloxacin and ofloxacin' type: journale userid: 4338 volume: 2