title: Bi- and Multivariate Analyses of Diallel Crosses: A Tool for the Genetic Dissection of Neurobehavioral Phenotypes
creator: Crusio, Wim E.
subject: Behavioral Neuroscience
description: The genetic-correlational approach provides a very powerful tool for the analysis of causal relationships between phenotypes. It appears to be particularly appropriate for investigating the functional organization of behavior and/or of causal relationships between brain and behavior. A method for the bivariate analysis of diallel crosses that permits the estimation of correlations due to environmental effects, additive-genetic effects, and/or dominance deviations is described, together with a worked-out example stemming from a five times replicated 4 x 4 diallel cross between inbred mouse strains. The phenotypes chosen to illustrate the analysis were locomotor activity and rearing frequency in an open field. Large, positive additive-genetic and dominance correlations between these two phenotypes were obtained. This finding was replicated in another, independently-executed, diallel cross.
date: 1993
type: Journal (Paginated)
type: PeerReviewed
format: text/html
identifier: http://cogprints.org/33/1/diallel2.htm
identifier:   Crusio, Wim E.  (1993) Bi- and Multivariate Analyses of Diallel Crosses: A Tool for the Genetic Dissection of Neurobehavioral Phenotypes.  [Journal (Paginated)]     
relation: http://cogprints.org/33/