TY  - GEN
ID  - cogprints33
UR  - http://cogprints.org/33/
A1  - Crusio, Wim E.
Y1  - 1993///
N2  - The genetic-correlational approach provides a very powerful tool for the analysis of causal relationships between phenotypes. It appears to be particularly appropriate for investigating the functional organization of behavior and/or of causal relationships between brain and behavior. A method for the bivariate analysis of diallel crosses that permits the estimation of correlations due to environmental effects, additive-genetic effects, and/or dominance deviations is described, together with a worked-out example stemming from a five times replicated 4 x 4 diallel cross between inbred mouse strains. The phenotypes chosen to illustrate the analysis were locomotor activity and rearing frequency in an open field. Large, positive additive-genetic and dominance correlations between these two phenotypes were obtained. This finding was replicated in another, independently-executed, diallel cross.
KW  - diallel cross
KW  -  genetic correlations
KW  -  multivariate analysis
KW  -  brain-behavior relationships
KW  -  neurobehavioral genetics
KW  -  exploratory activity
KW  -  mouse
TI  - Bi- and Multivariate Analyses of Diallel Crosses: A Tool for the Genetic Dissection of Neurobehavioral Phenotypes
SP  - 59
AV  - public
EP  - 67
ER  -

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