---
abstract: 'The genetic-correlational approach provides a very powerful tool for the analysis of causal relationships between phenotypes. It appears to be particularly appropriate for investigating the functional organization of behavior and/or of causal relationships between brain and behavior. A method for the bivariate analysis of diallel crosses that permits the estimation of correlations due to environmental effects, additive-genetic effects, and/or dominance deviations is described, together with a worked-out example stemming from a five times replicated 4 x 4 diallel cross between inbred mouse strains. The phenotypes chosen to illustrate the analysis were locomotor activity and rearing frequency in an open field. Large, positive additive-genetic and dominance correlations between these two phenotypes were obtained. This finding was replicated in another, independently-executed, diallel cross.'
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creators_name:
- family: Crusio
given: Wim E.
honourific: ''
lineage: ''
date: 1993
date_type: published
datestamp: 1998-05-07
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dir: disk0/00/00/00/33
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eprint_status: archive
eprintid: 33
fileinfo: /style/images/fileicons/text_html.png;/33/1/diallel2.htm
full_text_status: public
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ispublished: pub
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keywords: 'diallel cross, genetic correlations, multivariate analysis, brain-behavior relationships, neurobehavioral genetics, exploratory activity, mouse'
lastmod: 2011-03-11 08:53:37
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: ~
pagerange: 59-67
pubdom: FALSE
publication: Behavior Genetics
publisher: ~
refereed: TRUE
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reportno: ~
rev_number: 8
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status_changed: 2007-09-12 16:21:58
subjects:
- behav-neuro-sci
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title: 'Bi- and Multivariate Analyses of Diallel Crosses: A Tool for the Genetic Dissection of Neurobehavioral Phenotypes'
type: journalp
userid: 30
volume: 23