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TY - GEN ID - cogprints3316 UR - http://cogprints.org/3316/ A1 - KATZ, EMILY A1 - ROTHSCHILD, OLIVER A1 - HERRERA, ANDRIANA A1 - HUANG, SOFIA A1 - WONG, ANNA A1 - WOJCIECHOWSKI, YVETTE A1 - GIL, AIDA A1 - YAN, QI JIANG A1 - BAUCHWITZ, ROBERT TI - Odor Based Behavioral Tasks Confounded by Distance Dependent Detection: Modification of a Murine Digging Paradigm Y1 - 2003/12// N2 - Tests of murine higher order cognition are important in order to fully explore the effects of genetic alterations and potential therapies in models of human mental retardation and other deficits of intellect. In this study, inbred and F1 hybrid strains of mice were assessed in a five odor sequence task previously described for rats which employs buried food rewards. Data are provided indicating that the use of buried rewards in mouse olfactory digging tasks should be approached with significant caution. An alternate test of sequence dependent working memory (2-sequence task) using a post choice, drop-in food reward is described. After achievement of stable average plateau scores, a streak and slump pattern, rather than near errorless performance, was observed. Therefore, mice do not appear to effortlessly acquire sequences of odors in a working memory paradigm in which rewarded odors are constantly changing. AV - public KW - sequence memory KW - learning set KW - olfactory discrimination KW - digging tasks KW - episodic memory KW - Murine Olfactory Sequence Tasks KW - mouse KW - rat KW - rodent ER -