TY  - GEN
ID  - cogprints3871
UR  - http://cogprints.org/3871/
A1  - Highley, Dr JR
A1  - Walker, Ms M
A1  - McDonald, Dr B
A1  - Crow, Prof TJ
A1  - Esiri, Prof MM
Y1  - 2003///
N2  - Background Meta-analyses of
hippocampal size have indicated thatthis
structure is smaller in schizophrenia.This
could reflect a reductioninthe size of
constituent neurons or a reduced number
of neurons.
Aims To measure the size of
hippocampalpyramidalneuronsinthe hippocampalpyramidalneurons inthe
brains of peoplewith andwithout
schizophrenia.
Method Pyramidalneuron size in
hippocampal subfieldswas estimated
stereologically fromsections taken at
5mmintervals throughoutthewhole
length of right and left hippocampi from
andleft the brains of13 peoplewith schizophrenia
and16 controls.Resultswere assessed
using repeated-measures analysis of
covariance looking for amain effectof
diagnosis and gender, andinteractions of
and interactions thesewith side.
Results Wewere unable to detect
significantdifferences related to diagnosis,
gender or side for any hippocampal
subfield for this series of cases.
Conclusions For this series of brains,
hippocampal cell size is unchangedin
schizophrenia.

PB  - Wiley
TI  - Size of hippocampal pyramidal neurons in schizophrenia
SP  - 414
AV  - public
EP  - 417
ER  -

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