---
abstract: |
Background Meta-analyses of
hippocampal size have indicated thatthis
structure is smaller in schizophrenia.This
could reflect a reductioninthe size of
constituent neurons or a reduced number
of neurons.
Aims To measure the size of
hippocampalpyramidalneuronsinthe hippocampalpyramidalneurons inthe
brains of peoplewith andwithout
schizophrenia.
Method Pyramidalneuron size in
hippocampal subfieldswas estimated
stereologically fromsections taken at
5mmintervals throughoutthewhole
length of right and left hippocampi from
andleft the brains of13 peoplewith schizophrenia
and16 controls.Resultswere assessed
using repeated-measures analysis of
covariance looking for amain effectof
diagnosis and gender, andinteractions of
and interactions thesewith side.
Results Wewere unable to detect
significantdifferences related to diagnosis,
gender or side for any hippocampal
subfield for this series of cases.
Conclusions For this series of brains,
hippocampal cell size is unchangedin
schizophrenia.
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creators_name:
- family: Highley
given: JR
honourific: Dr
lineage: ''
- family: Walker
given: M
honourific: Ms
lineage: ''
- family: McDonald
given: B
honourific: Dr
lineage: ''
- family: Crow
given: TJ
honourific: Prof
lineage: ''
- family: Esiri
given: MM
honourific: Prof
lineage: ''
date: 2003
date_type: published
datestamp: 2004-12-04
department: ~
dir: disk0/00/00/38/71
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eprint_status: archive
eprintid: 3871
fileinfo: /style/images/fileicons/application_pdf.png;/3871/1/414Highley.pdf
full_text_status: public
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ispublished: pub
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lastmod: 2011-03-11 08:55:42
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number: ~
pagerange: 414-417
pubdom: TRUE
publication: British Journal of Psychiatry
publisher: Wiley
refereed: TRUE
referencetext: |+2
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title: Size of hippocampal pyramidal neurons in schizophrenia
type: journalp
userid: 5148
volume: 183