?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=The+Study+of+Serum+Prostate+Specific+Antigen+and+Phosphatase+Isoenzymes+Activity+as+Diagnostic+Parameters+in+Patients+with+Prostate+Cancer+in+Nigeria&rft.creator=Chidi+Uzoma%2C+Igwe&rft.creator=Chidiebere+Ikechukwu%2C+Ikaraoha&rft.creator=Jaye+Olasumbo%2C+Ogunlewe&rft.creator=Gilbert+Obiora%2C+Nwobu&rft.creator=Livinus+Ariri+Donatus%2C+Duru&rft.creator=Azukaego+Thomas+Hughs%2C+Mokogwu&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Serum+activities+of+Acid+Phosphatase+(ACP)+and+Prostatic+Acid+Phosphatase+(PAP)+are+still+employed+in+most+hospitals+in+Nigeria+for+the+diagnosis+of+prostate+cancer%2C+because+of+lack+of+resources+for+prostate+specific+antigen+(PSA)+assay.+Serum+PSA+and+activities+of+phosphatase+isoenzymes+ACP+and+PAP%2C+Alkaline+Phosphatase+(ALP)+and+Heat+stable+Alkaline+Phosphatase+(HSAP)+were+studied+in+71+apparently+healthy+male+controls+and+47+proven+prostate+cancer+patients.+There+were+statistically+significant+increases+in+the+mean+serum+levels+of+PSA%2C+PAP%2C+ACP%2C+ALP+and+HSAP+in+the+prostate+cancer+patients+compared+to+the+controls+(P%3C0.001).+PSA+level+was+increased+above+the+cut-off+level+in+85.1%25+of+patients%2C+PAP+in+66.0%25%2C+ACP+in+57.5%25%2C+ALP+in+34.0%25+and+HSAP+in+21.3%25+of+cases.+Serum+levels+of+PSA%2C+ACP+and+PAP+were+lower+and+of+ALP+and+HSAP+higher+in+patients+with+longer+duration+of+the+disease+(P%3C0.05).+The+study+confirms+the+relevance+of+PSA+assay+over+ACP%2C+PAP%2C+ALP+and+HSAP+in+the+diagnosis+of+prostate+cancer+patients.+It+highlights+the+need+for+the+inclusion+of+PSA+assay+in+hospitals+for+accurate+diagnosis+of+prostatic+carcinoma.&rft.publisher=Dr.+B.S.+Kakkilaya&rft.contributor=Kakkilaya+Bevinje%2C+Dr.+Srinivas&rft.date=2004-10&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F3899%2F1%2F2004-3-3.pdf&rft.identifier=++Chidi+Uzoma%2C+Igwe+and+Chidiebere+Ikechukwu%2C+Ikaraoha+and+Jaye+Olasumbo%2C+Ogunlewe+and+Gilbert+Obiora%2C+Nwobu+and+Livinus+Ariri+Donatus%2C+Duru+and+Azukaego+Thomas+Hughs%2C+Mokogwu++(2004)+The+Study+of+Serum+Prostate+Specific+Antigen+and+Phosphatase+Isoenzymes+Activity+as+Diagnostic+Parameters+in+Patients+with+Prostate+Cancer+in+Nigeria.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F3899%2F