?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Four+basic+symmetry+types+in+the+universal+7-cluster%0Astructure+of+143+complete+bacterial+genomic+sequences&rft.creator=Gorban%2C+A.N.&rft.creator=Popova%2C+T.G.&rft.creator=Zinovyev%2C+A.Yu.&rft.subject=Theoretical+Biology&rft.description=Coding+information+is+the+main+source+of+heterogeneity%0A(non-randomness)+in+the+sequences+of+bacterial+genomes.+This%0Ainformation+can+be+naturally+modeled+by+analysing+cluster+structures+in+the+%60%60in-phase''+triplet+distributions+of+relatively+short+genomic+fragments+(200-400bp).+We+found+a+universal+7-cluster+structure+in+all+143+completely+sequenced+bacterial+genomes+available+in+Genbank+in+August+2004%2C+and+explained+its+properties.%0AThe+7-cluster+structure+is+responsible+for+the+main+part+of+sequence+heterogeneity+in+bacterial+genomes.+In+this+sense%2C+our+7+clusters+is+the+basic+model+of+bacterial+genome+sequence.+We+demonstrated+that+there+are+four+basic+%60%60pure''+types+of+this+model%2C+observed+in+nature%3A+%60%60parallel+triangles''%2C+%60%60perpendicular+triangles''%2C%0Adegenerated+case+and+the+flower-like+type.+We+show+that+codon+usage+of+bacterial+genomes+is+a+multi-linear+function+of+their+genomic+G%2BC-content+with+high+accuracy+(more+precisely%2C+by+two+similar+functions%2C+one+for+eubacterial+genomes+and+the+other+one+for+archaea).%0A%0AAll+143+cluster+animated+3D-scatters+are+collected+in+a+database+and+is+made+available+on+our+web-site%3A%0A%0Ahttp%3A%2F%2Fwww.ihes.fr%2F~zinovyev%2F7clusters+%0A%0AThe+finding+can+be+readily+introduced+into+any+software+for+gene+prediction%2C+sequence+alignment+or+bacterial+genomes+classification.%0A&rft.date=2004-10&rft.type=Preprint&rft.type=NonPeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F3915%2F1%2F7clustersCog.pdf&rft.identifier=++Gorban%2C+A.N.+and+Popova%2C+T.G.+and+Zinovyev%2C+A.Yu.++(2004)+Four+basic+symmetry+types+in+the+universal+7-cluster+structure+of+143+complete+bacterial+genomic+sequences.++%5BPreprint%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F3915%2F