?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Factor+structure+and+familiality+of+first-rank+symptoms+in+sibling+pairs+with+schizophrenia+and+schizoaffective+disorder&rft.creator=Loftus%2C+Dr+J&rft.creator=DeLisi%2C+Prof+LE&rft.creator=Crow%2C+Prof+TJ&rft.subject=Behavioral+Neuroscience&rft.description=Background+Since+their+introduction+as+diagnostic+criteria+by+Schneider+in+1937%2C+nuclear+symptoms+have+played+a+key+role+in+concepts+of+schizophrenia%2C+but+their+relationship+to+each+other+and+to+genetic+predisposition+has+been+unclear.+%0A%0AAims+To+ascertain+the+factor+structure+and+familiality+of+nuclear+symptoms.+%0A%0AMethods+Nuclear+(Schneiderian)+symptoms+were+extracted+from+case+notes+and+interviews+in+a+study+of+103+sibling+pairs+with+DSM-III-R+schizophrenia+or+schizoaffective+disorder.+%0A%0AResults+Principal+components+analysis+demonstrated+two+major+factors+%3A+one%2C+accounting+for+about+50%25+of+the+variance%2C+groups+thought+withdrawal%2C+insertion+and+broadcasting%2C+with+delusions+of+control+%3B+and+the+second%2C+accounting+for+%3C20%25+of+the+variance%2C+groups+together+third-person+voices%2C+thought+echo+and+running+commentary.+Factor+I+was+significantly+correlated+within+sibling+pairs.+%0A%0AConclusions+The+correlation+within+sibling+pairs+suggests+that%2C+contrary+to+the+conclusion+of+some+previous+studies%2C+some+nuclear+symptoms+do+show+a+degree+of+familiality+and+therefore+perhaps+heritability.+%0A%0A&rft.date=2000&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F3971%2F1%2FLoftus2000.pdf&rft.identifier=++Loftus%2C+Dr+J+and+DeLisi%2C+Prof+LE+and+Crow%2C+Prof+TJ++(2000)+Factor+structure+and+familiality+of+first-rank+symptoms+in+sibling+pairs+with+schizophrenia+and+schizoaffective+disorder.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F3971%2F