?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Issues+in+QT+interval+measurement+&rft.creator=Lanjewar%2C+Pallavi&rft.creator=Pathak%2C+Vaishali&rft.creator=Lokhandwala%2C+Yash&rft.subject=Indian+Pacing+and+Electrophysiology+Journal&rft.description=The+QT+interval%2C+apart+from+clinical+implications+is+crucial+for+safety+assessment+of+new+drugs+under+development.+A+QTc+prolongation+of+even+10+msec+in+a+study+group+is+a+warning+signal+for+a+new+drug.+%0A++++++++++++There+are+various+issues+involved+in+the+measurement+of+the+QT+interval+especially+regarding+the+ending+of+the+T+wave+and+different+morphological+pattern+of+T-U+complex.+The+other+issue+is+significant+spontaneous+variability+in+the+QT+interval%2C+resulting+in+spurious+QT+prolongation+and+unnecessary+concern.%0A++++++++++++To+minimize+all+these+confounding+factors%2C+all+clinical+trials+for+assessing+QT+interval+prolongation+should+be+randomized+and+double+blinded+with+appropriate+control+groups+including+placebo.+ECG+measurements+should+be+done+by++trained+readers+with+electronic+calipers+at++ECG+core+Lab.+ECGs+should+be+compared++with+multiple+baseline+values+with+multiple%2C+time-matched+on-treatment+values.%0A&rft.publisher=Indian+Pacing+and+Electrophysiology+Group&rft.contributor=Singh%2C+Balbir&rft.contributor=Lokhandwala%2C+Yash&rft.contributor=Francis%2C+Johnson&rft.contributor=Gupta%2C+Anup&rft.date=2004-10&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F4178%2F1%2Fyash3.pdf&rft.identifier=++Lanjewar%2C+Pallavi+and+Pathak%2C+Vaishali+and+Lokhandwala%2C+Yash++(2004)+Issues+in+QT+interval+measurement.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F4178%2F