?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Role+of+Atrial+Fibrillation+Threshold+Evaluation+on+Guiding+Treatment&rft.creator=Shirayama%2C+Takeshi&rft.subject=Indian+Pacing+and+Electrophysiology+Journal&rft.description=Atrial+fibrillation+could+be+induced+reproducibly+by+50Hz+rapid+stimulation+which+was+given+through+systolic+and+early+diastolic+phase+of+atrial+excitation.+Duration+of+atrial+fibrillation+induced+in+this+way+was+roughly+dependent+on+the+current+amplitude+of+the+stimulation.+The+minimum+current+that+could+induce+long-lasting+atrial+fibrillation+(30sec+in+the+clinical+setting%2C+2sec+in+the+rabbit+or+rat+model)+was+defined+as+atrial+fibrillation+threshold+(AFT).+AFT+was+larger+in+patients+who+had+history+of+atrial+fibrillation+than+those+who+did+not.+Anti-arrhythmic+drugs+raised+AFT+by+various+degrees+both+in+experimental+and+clinical+cases.+Long-term+efficacy+of+a+drug+could+be+predicted+in+a+patient%2C+measuring+how+much+the+drug+increased+AFT+(cut-off+point+%3D+5mA+increase).+AFT+is+a+useful+marker+to+evaluate+atrial+vulnerability+and+to+guide+pharmacological+treatment+of+atrial+fibrillation.%0A&rft.publisher=Indian+Pacing+and+Electrophysiology+Group&rft.contributor=Singh%2C+Balbir&rft.contributor=Lokhandwala%2C+Yash&rft.contributor=Francis%2C+Johnson&rft.contributor=Gupta%2C+Anup&rft.date=2003-10&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F4248%2F1%2Fshirayama.htm&rft.identifier=++Shirayama%2C+Takeshi++(2003)+Role+of+Atrial+Fibrillation+Threshold+Evaluation+on+Guiding+Treatment.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F4248%2F