?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Brugada+Disease%3A+Chronology+Of+Discovery+And+Paternity.%0APreliminary+Observations+And+Historical+Aspects+&rft.creator=Riera%2C+Andr%C3%A9s+Ricardo+P%C3%A9rez&rft.creator=Schapachnik%2C+Edgardo&rft.creator=Ferreira%2C+Celso&rft.subject=Indian+Pacing+and+Electrophysiology+Journal&rft.description=The+Brugada+disease%2C+the+last+clinico-cardiologic+entity+described+in+the+20th+century%2C+initially+called+right+bundle+branch+block+syndrome+with+ST+segment+elevation+from+V1+to+V2+or+V3+and+sudden+cardiac+death%2C+is+genetically+determined+in+a+dominant+autosomal+mode%2C+and+it+affects+the+alpha+subunit+of+the+Na%2B+channel+by+alteration+of+chromosome+3+and+mutation+in+the+SCN5A+gene.%0A++++++++++++In+clinical+diagnosis+the+mentioned+electrocardiographic+pattern+in+a+patient+without+structural+heart+disease+and+positivity+in+pharmacological+tests+are+considered+major+criteria.+As+minor+criteria%2C+the+following+are+considered%3A+positive+family+history%2C+presence+of+syncope+with+unknown+origin%2C+documented+episode+of+VT%2FVF%2C+inducibility+in+electrophysiologic+study+and+positivity+of+genetic+study.+%0A++++++++++++The+long-standing+technology+of+ECG%2C+with+more+than+a+century+of+existence%2C+remains+as+the+supplementary+method+with+highest+value+in+diagnosis%2C+and+currently+new+electrocardiographic+criteria+are+suggested%2C+which+indicate+high+risk+of+VF.+%0A++++++++++++Natural+history+indicates+a+somber+diagnosis+in+symptomatic+patients+with+a+high+index+of+arrhythmic+SCD+secondary+to+very+fast+polymorphic+ventricular+tachycardia+bursts%2C+which+degenerate+into+VF.+Asymptomatic+individuals+with+only+a+Brugada-type+electrocardiographic+pattern+have+a+low+risk.+The+prognosis+seems+to+depend+more+on+clinical+facts%2C+since+a+positive+electrophysiologic+study+has+an+accuracy+of+just+around+50%25.+%0A++++++++++++We+propose+that+this+entity+should+be+promoted+to+the+category+of+disease%2C+since+it+has+a+characteristic+set+of+signs+and+symptoms%2C+and+an+identified+genetic+defect.+%0A&rft.publisher=Indian+Pacing+and+Electrophysiology+Group&rft.contributor=Singh%2C+Balbir&rft.contributor=Lokhandwala%2C+Yash&rft.contributor=Francis%2C+Johnson&rft.contributor=Gupta%2C+Anup&rft.date=2003-10&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F4251%2F1%2Friera.htm&rft.identifier=++Riera%2C+Andr%C3%A9s+Ricardo+P%C3%A9rez+and+Schapachnik%2C+Edgardo+and+Ferreira%2C+Celso++(2003)+Brugada+Disease%3A+Chronology+Of+Discovery+And+Paternity.+Preliminary+Observations+And+Historical+Aspects.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F4251%2F