@prefix epid: .
@prefix dc: .
@prefix geo: .
@prefix bibo: .
@prefix epx: .
@prefix owl: .
@prefix void: .
@prefix event: .
@prefix skos: .
@prefix xsd: .
@prefix cc: .
@prefix ep: .
@prefix foaf: .
@prefix rdf: .
@prefix rdfs: .
@prefix eprel: .
@prefix dct: .
<>
foaf:primaryTopic ;
rdfs:comment "The repository administrator has not yet configured an RDF license."^^xsd:string .
rdfs:label "cmj link.jpg"^^xsd:string .
rdfs:label "cmj.jpg"^^xsd:string .
rdfs:label "ipej_but_archives.gif"^^xsd:string .
rdfs:label "ipej_but_currentissue.gif"^^xsd:string .
rdfs:label "ipej_but_editors.gif"^^xsd:string .
rdfs:label "ipej_but_home.gif"^^xsd:string .
rdfs:label "ipej_logo_border.gif"^^xsd:string .
rdfs:label "ipej_title.gif"^^xsd:string .
rdfs:label "ithj.jpg"^^xsd:string .
rdfs:label "redarrow.gif"^^xsd:string .
rdfs:label "riera.htm"^^xsd:string .
rdfs:label "indexcodes.txt"^^xsd:string .
dc:format "text/html";
dc:title "HTML Summary of #4251 \n\nBrugada Disease: Chronology Of Discovery And Paternity.\nPreliminary Observations And Historical Aspects \n\n";
foaf:primaryTopic .
dct:hasPart ,
,
,
,
,
,
,
,
,
,
;
ep:hasFile ,
,
,
,
,
,
,
,
,
,
;
rdf:type bibo:Document,
ep:Document;
rdfs:label "Brugada Disease: Chronology Of Discovery And Paternity.\nPreliminary Observations And Historical Aspects (HTML)"^^xsd:string .
dct:hasPart ;
ep:hasFile ;
eprel:isIndexCodesVersionOf ;
eprel:isVersionOf ;
eprel:isVolatileVersionOf ;
rdf:type ep:Document;
rdfs:label "Brugada Disease: Chronology Of Discovery And Paternity.\nPreliminary Observations And Historical Aspects (Indexer Terms)"^^xsd:string .
rdf:_1 ;
rdf:_2 ;
rdf:_3 .
rdf:_1 ;
rdf:_2 ;
rdf:_3 ;
rdf:_4 .
,
,
,
;
bibo:abstract "The Brugada disease, the last clinico-cardiologic entity described in the 20th century, initially called right bundle branch block syndrome with ST segment elevation from V1 to V2 or V3 and sudden cardiac death, is genetically determined in a dominant autosomal mode, and it affects the alpha subunit of the Na+ channel by alteration of chromosome 3 and mutation in the SCN5A gene.\n In clinical diagnosis the mentioned electrocardiographic pattern in a patient without structural heart disease and positivity in pharmacological tests are considered major criteria. As minor criteria, the following are considered: positive family history, presence of syncope with unknown origin, documented episode of VT/VF, inducibility in electrophysiologic study and positivity of genetic study. \n The long-standing technology of ECG, with more than a century of existence, remains as the supplementary method with highest value in diagnosis, and currently new electrocardiographic criteria are suggested, which indicate high risk of VF. \n Natural history indicates a somber diagnosis in symptomatic patients with a high index of arrhythmic SCD secondary to very fast polymorphic ventricular tachycardia bursts, which degenerate into VF. Asymptomatic individuals with only a Brugada-type electrocardiographic pattern have a low risk. The prognosis seems to depend more on clinical facts, since a positive electrophysiologic study has an accuracy of just around 50%. \n We propose that this entity should be promoted to the category of disease, since it has a characteristic set of signs and symptoms, and an identified genetic defect. \n"^^xsd:string;
bibo:authorList ;
bibo:editorList ;
bibo:issue "4";
bibo:status ,
;
bibo:volume "3";
dct:creator ,
,
;
dct:date "2003-10";
dct:isPartOf ,
;
dct:publisher ;
dct:subject ;
dct:title "Brugada Disease: Chronology Of Discovery And Paternity.\nPreliminary Observations And Historical Aspects "^^xsd:string;
ep:hasDocument ,
;
rdf:type bibo:Article,
ep:EPrint,
ep:JournalpEPrint;
rdfs:seeAlso .
rdf:type skos:Concept;
skos:prefLabel "Indian Pacing and Electrophysiology Journal" .
foaf:name "Indian Pacing and Electrophysiology Group"^^xsd:string;
rdf:type foaf:Organization .
foaf:familyName "Lokhandwala"^^xsd:string;
foaf:givenName "Yash"^^xsd:string;
foaf:name "Yash Lokhandwala"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Singh"^^xsd:string;
foaf:givenName "Balbir"^^xsd:string;
foaf:name "Balbir Singh"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Francis"^^xsd:string;
foaf:givenName "Johnson"^^xsd:string;
foaf:name "Johnson Francis"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Gupta"^^xsd:string;
foaf:givenName "Anup"^^xsd:string;
foaf:name "Anup Gupta"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Riera"^^xsd:string;
foaf:givenName "Andrés Ricardo Pérez"^^xsd:string;
foaf:name "Andrés Ricardo Pérez Riera"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Schapachnik"^^xsd:string;
foaf:givenName "Edgardo"^^xsd:string;
foaf:name "Edgardo Schapachnik"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Ferreira"^^xsd:string;
foaf:givenName "Celso"^^xsd:string;
foaf:name "Celso Ferreira"^^xsd:string;
rdf:type foaf:Person .
foaf:name "Indian Pacing and Electrophysiology Journal"^^xsd:string;
rdf:type bibo:Collection .