%A Andr?s Ricardo P?rez Riera %A Edgardo Schapachnik %A Celso Ferreira %J Indian Pacing and Electrophysiology Journal %T Brugada Disease: Chronology Of Discovery And Paternity. Preliminary Observations And Historical Aspects %X The Brugada disease, the last clinico-cardiologic entity described in the 20th century, initially called right bundle branch block syndrome with ST segment elevation from V1 to V2 or V3 and sudden cardiac death, is genetically determined in a dominant autosomal mode, and it affects the alpha subunit of the Na+ channel by alteration of chromosome 3 and mutation in the SCN5A gene. In clinical diagnosis the mentioned electrocardiographic pattern in a patient without structural heart disease and positivity in pharmacological tests are considered major criteria. As minor criteria, the following are considered: positive family history, presence of syncope with unknown origin, documented episode of VT/VF, inducibility in electrophysiologic study and positivity of genetic study. The long-standing technology of ECG, with more than a century of existence, remains as the supplementary method with highest value in diagnosis, and currently new electrocardiographic criteria are suggested, which indicate high risk of VF. Natural history indicates a somber diagnosis in symptomatic patients with a high index of arrhythmic SCD secondary to very fast polymorphic ventricular tachycardia bursts, which degenerate into VF. Asymptomatic individuals with only a Brugada-type electrocardiographic pattern have a low risk. The prognosis seems to depend more on clinical facts, since a positive electrophysiologic study has an accuracy of just around 50%. We propose that this entity should be promoted to the category of disease, since it has a characteristic set of signs and symptoms, and an identified genetic defect. %N 4 %K Brugada Disease, Brugada Syndrome, "prehistory," history %P 253-260 %E Balbir Singh %E Yash Lokhandwala %E Johnson Francis %E Anup Gupta %V 3 %D 2003 %I Indian Pacing and Electrophysiology Group %L cogprints4251