creators_name: Francis, Johnson
creators_name: Antzelevitch, Charles
editors_name: Singh, Balbir
editors_name: Lokhandwala, Yash
editors_name: Francis, Johnson
editors_name: Gupta, Anup
type: journalp
datestamp: 2005-04-20
lastmod: 2011-03-11 08:55:58
metadata_visibility: show
title: Brugada-Like Electrocardiographic Pattern
ispublished: pub
subjects: ipej
full_text_status: public
keywords: Brugada-Like Electrocardiographic Pattern
abstract:  The Brugada syndrome is characterized by a ST-segment elevation in the right precordial leads associated with right bundle branch block (RBBB) pattern and a propensity for life-threatening ventricular arrhythmias in the absence of structural heart disease.1 Mutations in a cardiac sodium channel gene have been linked to this syndrome2.

            The mechanism underlying the RBBB and ST-segment elevation in right precordial leads in patients with the Brugada syndrome is thought to be an outward shift of the ionic currents during early repolarization causing a marked accentuation of the action potential notch in right ventricular epicardial but not endocardial cells. The outward shift of current ultimately leads to loss of the action potential dome causing marked abbreviation of the action potential in the right ventricular epicardial cells.3, 4,
date: 2003-07
date_type: published
publication: Indian Pacing and Electrophysiology Journal
volume: 3
number: 3
publisher: Indian Pacing and Electrophysiology Group
pagerange: 91-92
refereed: TRUE
referencetext: 1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol 1992; 20:1391–1396.

2. Chen Q, Kirsch GE, Zhang D, et al. Genetic basis and molecular mechanisms for idiopathic ventricular fibrillation. Nature 1998; 392:293–296.

3. Antzelevitch C. The Brugada syndrome: Diagnostic criteria and cellular mechanisms. Eur Heart J 2001; 22:356–363.

4. Antzelevitch, C. Late potentials and the Brugada syndrome. Journal of American College of Cardiology 2002;39:1996-1999.

5. Antzelevitch, C., Brugada, P., Brugada, J., Brugada, R., Shimizu, W., Gussak, I., & Perez Riera, A. R.  Brugada Syndrome: A Decade of Progress. Circulation Research 2002; 91:1114-1118.

6.  Tarin N, Farre J, Rubio JM, et al. Brugada-like electrocardiographic pattern in a patient with a mediastinal tumor. PACE 1999; 22:1264–1266.

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9. Antzelevitch, C. & Dumaine, R. (2002). Electrical heterogeneity in the heart: Physiological, pharmacological and clinical implications. In Handbook of Physiology. The Heart., eds. Page, E., Fozzard, H. A., & Solaro, R. J., pp. 654-692. Oxford University Press, New York.

10.  Ortega-Carnicer J, Benezet J, Ruiz-Lorenzo F, Alcazar R. Transient Brugada-type electrocardiographic abnormalities in renal failure reversed by dialysis. Resuscitation 2002;55:215-9.

11.  Littmann L, Monroe MH, Svenson RH. Brugada-type electrocardiographic pattern induced by cocaine. Mayo Clin Proc 2000;75:845-9

12.  Saura D, Garcia-Alberola A, Carrillo P, Pascual D, Martinez-Sanchez J, Valdes M. Brugada-like electrocardiographic pattern induced by fever. Pacing Clin Electrophysiol 2002 May;25(5):856-9. 

13.  Shimizu W, Aiba T, Kurita T, Kamakura S. Paradoxic abbreviation of repolarization in epicardium of the right ventricular outflow tract during augmentation of Brugada-type ST segment elevation. J Cardiovasc Electrophysiol 2001;12:1418-21.
citation:   Francis, Johnson and Antzelevitch, Charles  (2003) Brugada-Like Electrocardiographic Pattern.  [Journal (Paginated)]     
document_url: http://cogprints.org/4256/1/francis3.htm