---
abstract: 'In 1992 a new syndrome consisting of syncopal episodes and/or sudden death in patients with a structurally normal heart and a characteristic electrocardiogram (ECG) with a pattern of right bundle branch block with an ST segment elevation in leads V1 to V3 was described 1 In 1998 the poor prognosis of patients with the syndrome not receiving an implantable defibrillator was reported 2,3 In 1998 the genetic nature of the disease and its assotiation to a mutation in the cardiac sodium channel gene was described 4 . Because the diagnosis is easily made by means of the ECG, an increasing number of patients with the ECG pattern are being identified worldwide. In this article we will review our present knowledge concerning patients with the classical ECG pattern of the disease. '
altloc:
  - http://www.ipej.org/0101/oct2001.htm
chapter: ~
commentary: ~
commref: ~
confdates: ~
conference: ~
confloc: ~
contact_email: ~
creators_id: []
creators_name:
  - family: Brugada
    given: Josep
    honourific: ''
    lineage: ''
  - family: Brugada
    given: Pedro
    honourific: ''
    lineage: ''
  - family: Brugada
    given: Ramon
    honourific: ''
    lineage: ''
date: 2001-10
date_type: published
datestamp: 2005-05-02
department: ~
dir: disk0/00/00/43/28
edit_lock_since: ~
edit_lock_until: ~
edit_lock_user: ~
editors_id: []
editors_name:
  - family: Singh
    given: Balbir
    honourific: ''
    lineage: ''
  - family: Lokhandwala
    given: Yash
    honourific: ''
    lineage: ''
  - family: Francis
    given: Johnson
    honourific: ''
    lineage: ''
  - family: Gupta
    given: Anup
    honourific: ''
    lineage: ''
eprint_status: archive
eprintid: 4328
fileinfo: /style/images/fileicons/text_html.png;/4328/1/brugada.htm
full_text_status: public
importid: ~
institution: ~
isbn: ~
ispublished: pub
issn: ~
item_issues_comment: []
item_issues_count: 0
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item_issues_id: []
item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: "Right Bundle Branch Block; ST segment Elevation in V1 to V3; Sudden Death\n"
lastmod: 2011-03-11 08:56:02
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 1
pagerange: 6-11
pubdom: TRUE
publication: Indian Pacing and Electrophysiology Journal
publisher: Indian Pacing and Electrophysiology Group
refereed: TRUE
referencetext: |-
  1.    Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: A distinct clinical and electrocardiographic syndrome. J Am Coll Cardiol 1992;20:1391-1396. Medline
  
  2.    Brugada J, Brugada R, Brugada P. Right bundle branch block and ST segment elevation in leads V1-V3: A marker for sudden death in patients with no demonstrable structural heart disease. Circulation 1998;97:457-460. Medline
  
  3.    Nademanee K, Veerakul G, Nimmannit S, et al. Arrhythmogenic marker for the sudden unexplained death syndrome in Thai men. Circulation 1997;96:2595-2600. Medline
  
  4.    Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, et al. Genetic basis and molecular mechanisms for idiopathic ventricular fibrillation. Nature; 1998;392:293-296. Medline
  
  5.    Tohyou Y, Nakazawa K Ozawa A, et al. A survey in the incidence of right bundle branch block with ST segment elevation among normal population. Jpn J Electrocardiol 1995;15:223-226. (No Abstract Available)
  
  6.    Namiki T, Ogura T, Kuwabara Y, et al. Five-year mortality and clinical characteristics of adult subjects with right bundle branch block and ST elevation. Circulation 1995;93:334. Medline
  
  7.    Hata Y, Chiba N, Hotta K, et al. Incidence and clinical significance of right bundle branch block and ST segment elevation in V1-V3 in 6-to 18-year-old school children in Japan. Circulation 1997;20:2310. (No Abstract Available)
  
  8.    Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S. Autonomic and antiarrhythmic modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol 1996;27:1061-1070. Medline
  
  9.    Antzelevitch C: The Brugada syndrome. J Cardiovasc Electrophysiol 1998;9:513-516. (No Abstract Available)
  
  10.    Gussak I, Antzelevitch C, Bjerregaard P, Towbin JA, Chaitman BR. The Brugada syndrome. Clinical, electrophysiologic and genetic aspects. J Am Coll Cardiol 1999;33:5-15. Medline
  
  11.    Priori SG, Diehl L, Schwartz PJ. Torsade de pointes. In: Podrid PJ, Kowey PR, eds. Cardiac Arrhythmia. Williams and Wilkins, Baltimore 1995,  p 951-963.
relation_type: []
relation_uri: []
reportno: ~
rev_number: 8
series: ~
source: ~
status_changed: 2007-09-12 16:58:27
subjects:
  - ipej
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: 'Brugada Syndrome: The Syndrome of Right Bundle Branch Block, ST segment Elevation in V1 to V3 and Sudden Death'
type: journalp
userid: 4424
volume: 1
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