---
abstract: 'Neurons are highly specialized cells that input, process, store and output information. Interneuronal communication is achieved in four basic ways: (i) Ca2+ evoked exocytosis with chemical neurotransmission, (ii) gap junction electrotonic coupling, (iii) secretion of neurosteroids, nitric oxide and derivatives of the arachidonic acid acting in paracrine manner, and (iv) cellular adhesive protein interactions with scaffold protein reorganization. Central structure integrating these anisomorphic signals is the neuronal cytoskeleton that is considered to be both sensitive to the local electromagnetic field and prone to intense biochemical modification. With the use of biophysical modeling we have shown that the local electromagnetic field interaction with neuronal microtubules could result in formation of dissipationless waves (solitons) of tubulin tail conformational states that propagate along the microtubule outer surface. Soliton collisions may subserve the function of elementary computational gates and the output of the computation performed by the microtubules may be achieved by the energase action of the tubulin tails that control microtubule-associated protein and motor protein attachment/detachment on the microtubule outer surface.'
altloc: []
chapter: ~
commentary: ~
commref: ~
confdates: ~
conference: ~
confloc: ~
contact_email: ~
creators_id: []
creators_name:
  - family: Georgiev
    given: Danko
    honourific: ''
    lineage: ''
  - family: Papaioanou
    given: Stelios
    honourific: ''
    lineage: ''
  - family: Glazebrook
    given: James
    honourific: ''
    lineage: ''
date: 2004-08
date_type: published
datestamp: 2005-05-27
department: ~
dir: disk0/00/00/43/64
edit_lock_since: ~
edit_lock_until: ~
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editors_id: []
editors_name:
  - family: Chaldakov
    given: George
    honourific: ''
    lineage: ''
  - family: Marani
    given: Enrico
    honourific: ''
    lineage: ''
  - family: Mathison
    given: Ronald
    honourific: ''
    lineage: ''
  - family: Yamamoto
    given: Hiroshi
    honourific: ''
    lineage: ''
eprint_status: archive
eprintid: 4364
fileinfo: /style/images/fileicons/application_pdf.png;/4364/1/BMR_2004_15_67%2D75.pdf
full_text_status: public
importid: ~
institution: ~
isbn: ~
ispublished: pub
issn: ~
item_issues_comment: []
item_issues_count: 0
item_issues_description: []
item_issues_id: []
item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'microtubule biology, tubulin tails, solitons, energase, subneuronal processing of information'
lastmod: 2011-03-11 08:56:04
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: ~
pagerange: 67-75
pubdom: FALSE
publication: Biomedical Reviews
publisher: 'The Bulgarian-American Center, Varna, Bulgaria'
refereed: TRUE
referencetext: ~
relation_type: []
relation_uri: []
reportno: ~
rev_number: 12
series: ~
source: ~
status_changed: 2007-09-12 16:59:16
subjects:
  - bio-phys
  - neuro-physio
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: 'NEURONIC SYSTEM INSIDE NEURONS: MOLECULAR BIOLOGY AND BIOPHYSICS OF NEURONAL MICROTUBULES'
type: journalp
userid: 3568
volume: 15
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